| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SK2; hSK2; SKCA2; KCa2.2; SKCa 2 |
| WB Predicted band size | 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KCNN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与KCNN2抗体相关的模拟参考文献(基于领域知识构造，非真实文献)：
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1. **文献名称**: *"KCNN2 channels in neuronal excitability and neurodevelopmental disorders"*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性KCNN2抗体，通过免疫组化和Western blot技术，揭示了KCNN2蛋白在小鼠海马神经元中的亚细胞定位。研究发现KCNN2表达异常与自闭症模型中突触可塑性受损相关。
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2. **文献名称**: *"Role of KCNN2 in cardiac fibrosis: Insights from antibody-based inhibition studies"*
**作者**: Chen L, et al.
**摘要**: 通过开发高亲和力KCNN2单克隆抗体，研究者发现抑制KCNN2通道活性可减轻心肌纤维化大鼠模型的病理进展，提示KCNN2可能成为心血管疾病的治疗靶点。
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3. **文献名称**: *"KCNN2 as a biomarker for glioblastoma progression"*
**作者**: Rodriguez M, et al.
**摘要**: 利用KCNN2抗体对脑胶质瘤组织进行免疫荧光分析，发现KCNN2蛋白表达水平与肿瘤侵袭性呈正相关，提示其可作为预后标志物和潜在治疗靶点。
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**注**：以上文献为示例性内容，实际引用需通过PubMed/Google Scholar等平台检索真实文献(例如搜索关键词：KCNN2 antibody, SK2 channel, KCNN2 biomarker)。
The KCNN2 antibody targets the KCNN2 protein, a member of the small-conductance calcium-activated potassium (SK) channel family. These channels, encoded by the *KCNN2* gene, regulate cellular excitability and calcium signaling by mediating potassium efflux in response to intracellular calcium increases. KCNN2 channels are critical in modulating neuronal afterhyperpolarization, shaping action potential firing patterns, and influencing synaptic plasticity, particularly in the central nervous system. Dysregulation of KCNN2 has been implicated in neurological disorders, including epilepsy, ataxia, and schizophrenia, as well as cardiovascular conditions like hypertension.
KCNN2 antibodies are essential tools for studying the protein's expression, localization, and function in tissues. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate KCNN2 distribution in brain regions, cardiomyocytes, and immune cells. Commercial antibodies are typically raised against specific epitopes, such as the cytoplasmic N- or C-terminal domains, and validated for specificity using knockout controls. Recent research also explores KCNN2's role in cancer progression and immune regulation, highlighting its potential as a therapeutic target. However, variability in antibody performance across species or experimental conditions necessitates careful validation to ensure reliability in diverse applications.
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