| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ACPP; 5'-NT; ACP-3; TM-PAP |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ACP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACP3抗体的3篇参考文献示例(注：以下内容为模拟生成，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *"Characterization of ACP3 as a Potential Biomarker in Prostate Cancer Using a Novel Monoclonal Antibody"*
**作者**: Zhang Y, et al.
**摘要**: 研究团队开发了一种针对ACP3(酸性磷酸酶3)的新型单克隆抗体，验证了其在前列腺癌组织中的特异性结合能力。实验表明，ACP3高表达与肿瘤转移风险相关，提示其可能作为预后标志物。
2. **文献名称**: *"Role of ACP3 in Osteoclast Differentiation: Insights from Antibody-Mediated Inhibition Studies"*
**作者**: Tanaka K, et al.
**摘要**: 通过抗ACP3抗体阻断实验，揭示了ACP3在破骨细胞分化中的关键作用。研究发现，抑制ACP3活性可减少骨吸收，为治疗骨质疏松提供了潜在靶点。
3. **文献名称**: *"Development of a High-Sensitivity ELISA Kit for ACP3 Detection in Serum"*
**作者**: Müller S, et al.
**摘要**: 报道了一种基于ACP3抗体的ELISA检测方法，用于定量分析血清中的ACP3水平。该方法在卵巢癌患者中显示出高灵敏度和特异性，可能辅助早期诊断。
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如需具体文献，建议通过 **PubMed** 或 **Web of Science** 检索关键词“ACP3 antibody”、“ACP3 acid phosphatase”等获取最新研究。
ACP3 antibody targets acid phosphatase 3 (ACP3), also known as lysosomal acid phosphatase or tartrate-resistant acid phosphatase (TRAP). This enzyme, encoded by the *ACP3* gene, is a metalloproteinase involved in hydrolyzing phosphate esters in acidic environments. Primarily expressed in osteoclasts, macrophages, and certain cancer cells, ACP3 plays critical roles in bone resorption, immune regulation, and cellular metabolism. Its tartrate-resistant isoform (TRAP) is a biomarker for osteoclast activity and bone-related disorders like osteoporosis.
In oncology, ACP3/TRAP overexpression is linked to cancer progression, particularly in aggressive prostate, breast, and lung cancers, where it may promote metastasis via extracellular matrix remodeling. ACP3 antibodies are essential tools for detecting enzyme expression in research and diagnostics. They enable studies on ACP3's functional mechanisms, its role in bone diseases, and its potential as a therapeutic target. Commercial ACP3 antibodies are typically validated for techniques like Western blotting, immunohistochemistry, and ELISA.
Recent studies explore ACP3 inhibitors for treating bone disorders or cancer, though clinical applications remain under investigation. The antibody's utility extends to distinguishing TRAP isoforms in pathological samples, aiding in both basic research and clinical diagnostics.
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