| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha |
| WB Predicted band size | 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL18R1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于IL18R1抗体的参考文献(基于公开文献信息模拟整理，非真实引用)：
1. **"IL-18R1-dependent mechanisms in inflammatory arthritis"**
*作者：Smith A, et al.*
摘要：研究通过IL18R1抗体阻断IL-18信号通路，发现其显著减轻小鼠模型中关节炎的炎症反应和关节损伤，表明IL18R1可能作为自身免疫疾病的治疗靶点。
2. **"Targeting IL18R1 in allergic asthma: A monoclonal antibody approach"**
*作者：Chen L, et al.*
摘要：开发了一种人源化IL18R1单克隆抗体，体外实验显示其有效抑制IL-18诱导的Th1细胞活化和炎症因子释放，提示其在哮喘等过敏性疾病中的潜在应用。
3. **"IL18R1 as a biomarker in sepsis: Antibody-based detection and clinical correlation"**
*作者：Wang X, et al.*
摘要：利用IL18R1特异性抗体检测脓毒症患者外周血单核细胞表面受体表达水平，发现高表达与疾病严重程度和预后不良显著相关，提示其作为预后标志物的潜力。
注：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar等平台检索确认。
The IL18R1 antibody targets the Interleukin-18 Receptor 1 (IL-18R1), a key component of the interleukin-1 (IL-1) receptor superfamily. IL-18R1 is a transmembrane protein that serves as the alpha subunit of the IL-18 receptor complex, partnering with IL-18RAP (beta subunit) to mediate signaling upon binding to its ligand, IL-18. This cytokine receptor plays a critical role in both innate and adaptive immunity, particularly in promoting inflammatory responses. IL-18 signaling activates downstream pathways, such as NF-κB and MAPK, leading to the production of pro-inflammatory cytokines like IFN-γ, which is vital for host defense against pathogens and in autoimmune diseases.
Antibodies against IL18R1 are widely used in research to study its expression, function, and regulation in immune cells, including T cells, macrophages, and dendritic cells. They enable detection via techniques like flow cytometry, immunohistochemistry, and Western blotting. Function-blocking IL18R1 antibodies are also employed to investigate the receptor's role in disease models, such as rheumatoid arthritis, inflammatory bowel disease, and sepsis, where dysregulated IL-18 signaling contributes to pathology. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher specificity for targeted applications. Recent advances in recombinant antibody technology have enhanced their utility in therapeutic research, particularly in exploring IL-18R1 neutralization as a potential strategy to modulate excessive inflammation. However, clinical applications remain experimental, underscoring the need for further validation of safety and efficacy.
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