Rabbit Polyclonal ARL6 Antibody

The ARL6 antibody is a crucial tool for studying the ADP-ribosylation factor-like 6 (ARL6) protein, encoded by the *ARL6* gene in humans. ARL6 belongs to the ARF/ARL family of small GTPases, which regulate intracellular trafficking and membrane dynamics. Notably, ARL6 is localized to primary cilia and plays a pivotal role in ciliary function, particularly in the assembly and maintenance of the Bardet-Biedl syndrome (BBSome) complex, a critical mediator of ciliary protein trafficking. Mutations in *ARL6* are linked to Bardet-Biedl syndrome type 3 (BBS3), a rare autosomal recessive ciliopathy characterized by retinal degeneration, obesity, polydactyly, and renal abnormalities. ARL6 antibodies are widely used in research to detect protein expression, assess subcellular localization (e.g., ciliary vs. cytoplasmic distribution), and investigate molecular mechanisms underlying ciliopathies. These antibodies are validated in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the study of ARL6's interaction with BBSome components and its role in signaling pathways like Hedgehog. Their application extends to disease modeling, drug discovery, and functional studies of cilia-related disorders.