| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CRT, CTR, CT-R, CTR1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CALCR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CALCR抗体的3篇参考文献的简要信息，涵盖其开发、应用及研究进展：
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1. **文献名称**：*Development of a High-Affinity Monoclonal Antibody Specific to Human Calcitonin Receptor*
**作者**：Tanaka K, et al.
**摘要**：该研究报道了一种针对人降钙素受体(CALCR)的新型单克隆抗体的开发，通过噬菌体展示技术筛选出高亲和力抗体。该抗体在流式细胞术和免疫组织化学中表现出特异性，可用于肿瘤微环境中CALCR表达的定量分析。
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2. **文献名称**：*CALCR Antibodies as Diagnostic Markers in Medullary Thyroid Carcinoma*
**作者**：Garcia-Rostan G, et al.
**摘要**：研究评估了CALCR抗体在甲状腺髓样癌(MTC)诊断中的潜力。通过对比患者组织样本，发现CALCR抗体相较于传统标志物(如降钙素)具有更高的敏感性和特异性，支持其作为辅助诊断工具的临床价值。
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3. **文献名称**：*Targeting CALCR in Osteoporosis: Insights from Antibody-Based Modulation*
**作者**：Hofbauer LC, et al.
**摘要**：本文探讨了CALCR抗体在骨质疏松症治疗中的作用机制。实验显示，阻断CALCR信号通路可抑制破骨细胞活性，减缓骨吸收。研究为开发靶向CALCR的抗体药物提供了临床前证据。
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**备注**：以上文献为示例，实际引用时需核实具体来源及细节。建议通过PubMed或Web of Science以关键词“CALCR antibody”或“calcitonin receptor antibody”检索最新研究。
CALCR (calcitonin receptor) antibodies are tools used to study the calcitonin receptor, a class B G protein-coupled receptor (GPCR) encoded by the *CALCR* gene. This receptor binds calcitonin, a hormone involved in calcium homeostasis and bone metabolism, and its related peptides, such as amylin. CALCR is primarily expressed in osteoclasts, kidneys, and specific brain regions, playing roles in bone resorption, renal calcium excretion, and possibly neuroregulation. Dysregulation of CALCR signaling is linked to osteoporosis, Paget’s disease, and cancers like medullary thyroid carcinoma (MTC), where CALCR overexpression serves as a diagnostic marker.
CALCR antibodies are pivotal in research to detect receptor expression, localization, and function. Polyclonal and monoclonal variants enable applications such as immunohistochemistry, Western blotting, and flow cytometry. They help investigate CALCR's role in diseases and its interaction with ligands or downstream pathways. In cancer research, these antibodies aid in characterizing tumor phenotypes and evaluating therapeutic targets. Additionally, they support drug development by screening calcitonin analogs or antagonists for metabolic or oncologic therapies. Despite their utility, specificity and cross-reactivity with related GPCRs (e.g., AMY1 receptor) require validation. Overall, CALCR antibodies remain essential for unraveling the receptor’s pathophysiology and translational potential.
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