| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KRT6A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT6A抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用请核实原文)：
1. **文献名称**：*KRT6A Expression in Psoriatic Epidermis: A Comparative Study Using Monoclonal Antibodies*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化技术，利用KRT6A特异性单克隆抗体分析了银屑病患者皮肤组织中KRT6A的表达模式，发现其在病变区域的过度表达与表皮增殖异常相关。
2. **文献名称**：*Role of Keratin 6A in Wound Healing: Insights from Antibody-Based Detection*
**作者**：Lee H, et al.
**摘要**：通过Western blot和免疫荧光技术，使用抗KRT6A抗体探究其在皮肤创伤修复中的作用，证实KRT6A在角质形成细胞迁移和再上皮化过程中显著上调。
3. **文献名称**：*KRT6A as a Biomarker in Oral Squamous Cell Carcinoma: Immunohistochemical Analysis*
**作者**：Garcia R, et al.
**摘要**：采用抗KRT6A抗体对口腔鳞癌组织进行免疫组化染色，发现KRT6A的高表达与肿瘤侵袭性和不良预后相关，提示其作为潜在诊断标志物的价值。
(提示：实际文献检索建议通过PubMed或Google Scholar以“KRT6A antibody”为关键词查询近年研究。)
The KRT6A antibody is a valuable tool for detecting keratin 6A, a type II intermediate filament protein encoded by the *KRT6A* gene. Keratin 6A, part of the keratin family, is primarily expressed in epithelial tissues, particularly in the skin, hair follicles, nails, and oral mucosa. It plays a critical role in maintaining structural integrity, cell signaling, and stress response in keratinocytes. KRT6A is notably upregulated in hyperproliferative or damaged skin, such as during wound healing or in psoriasis.
Mutations in *KRT6A* are linked to genetic disorders like pachyonychia congenita (PC), a rare autosomal dominant condition characterized by painful palmoplantar keratoderma, nail dystrophy, and oral lesions. The KRT6A antibody is widely used in research and diagnostics to study keratinocyte differentiation, epithelial pathologies, and cancer biology, as aberrant KRT6A expression is observed in certain squamous cell carcinomas.
In laboratory settings, this antibody is applied in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to visualize KRT6A distribution and expression levels. Its specificity helps distinguish KRT6A from other keratin isoforms (e.g., KRT6B/C), aiding in precise disease subtyping and mechanistic studies. By elucidating KRT6A's role in epithelial homeostasis and disease, this antibody contributes to advancing therapeutic strategies for keratin-related disorders and epithelial cancers.
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