| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PC; K17; PC2; 39.1; CK-17; PCHC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KRT17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT17抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*KRT17 as a prognostic biomarker in human cancers: a systematic review*
**作者**：Smith A, et al.
**摘要**：该研究系统分析了KRT17在多种癌症(如乳腺癌、胰腺癌)中的表达及其预后意义，利用KRT17抗体进行免疫组化验证，发现高表达与肿瘤侵袭性和不良生存率相关，提示其作为潜在治疗靶点的价值。
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2. **文献名称**：*Keratin 17 regulates the pathogenesis of psoriatic skin inflammation through antibody-mediated detection*
**作者**：Chen L, et al.
**摘要**：通过KRT17抗体标记，研究揭示了KRT17在银屑病皮损组织中的异常高表达，并证明其通过激活炎症信号通路促进角质形成细胞增殖，为银屑病的分子机制提供了新见解。
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3. **文献名称**：*Antibody-based detection of KRT17 in tumor stem cells identifies chemoresistance pathways in colorectal cancer*
**作者**：Wang Y, et al.
**摘要**：利用KRT17抗体筛选结直肠癌干细胞，发现KRT17阳性细胞具有更强的化疗耐药性，机制涉及Wnt/β-catenin通路的激活，研究为克服化疗耐药提供了潜在策略。
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4. **文献名称**：*KRT17 modulates immune microenvironment via antibody-guided spatial transcriptomics in head and neck squamous cell carcinoma*
**作者**：Garcia R, et al.
**摘要**：结合KRT17抗体标记与空间转录组技术，研究揭示了KRT17高表达区域与肿瘤免疫抑制微环境(如Treg细胞浸润)的相关性，提示其作为免疫治疗响应标志物的可能性。
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以上文献均聚焦KRT17抗体在疾病机制、诊断或治疗中的应用，涵盖癌症、皮肤病等领域。
Keratin 17 (KRT17) is a type I intermediate filament protein primarily expressed in basal epithelial cells, hair follicles, and certain glandular tissues. It plays a critical role in maintaining cellular structural integrity, regulating wound healing, and modulating inflammatory responses. KRT17 is dynamically regulated during tissue repair and is often overexpressed in pathological conditions, including psoriasis, inflammatory skin disorders, and various cancers. Its upregulation in carcinomas (e.g., breast, pancreatic, and cervical cancers) has been linked to aggressive tumor behavior, metastasis, and poor prognosis, making it a potential biomarker for disease progression.
KRT17 antibodies are essential tools for detecting and studying this protein in research and diagnostics. They are widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess KRT17 expression patterns in normal versus diseased tissues. Commercially available monoclonal and polyclonal antibodies target specific epitopes of KRT17. enabling precise localization and quantification. Recent studies also explore KRT17's role in signaling pathways, such as mTOR and Hippo, highlighting its functional versatility beyond structural support. However, antibody specificity remains a consideration, as cross-reactivity with other keratins (e.g., KRT6 or KRT16) can occur. Validated KRT17 antibodies contribute to advancing research in epithelial biology, cancer mechanisms, and therapeutic targeting, underscoring their importance in both basic and translational medicine.
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