| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FHF1, FGF12B |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FGF12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FGF12抗体的3篇参考文献示例(内容为模拟概括，建议通过学术数据库核实具体文献)：
1. **文献名称**：*FGF12 modulates epileptogenesis through protein-protein interactions with voltage-gated sodium channels*
**作者**：Smith A, et al.
**摘要**：研究利用FGF12特异性抗体分析其与钠通道的相互作用，发现FGF12在癫痫模型中通过调控神经元兴奋性影响疾病进程。
2. **文献名称**：*FGF12 expression in cardiac development and disease: Insights from antibody-based localization*
**作者**：Chen L, et al.
**摘要**：通过免疫组化(使用FGF12抗体)揭示FGF12在心脏发育中的时空表达模式，并探讨其突变与心律失常的关联。
3. **文献名称**：*Antibody-mediated inhibition of FGF12 signaling attenuates neuropathic pain in rodent models*
**作者**：Wang X, et al.
**摘要**：开发FGF12中和抗体，验证其在抑制背根神经节FGF12信号传导及缓解神经病理性疼痛中的治疗潜力。
如需具体文献，建议在PubMed或Google Scholar中检索“FGF12 antibody” + 研究领域(如“epilepsy”“cardiac”“signaling”)获取近年研究。
Fibroblast Growth Factor 12 (FGF12) is a member of the fibroblast growth factor family, which regulates diverse biological processes, including cell proliferation, differentiation, and tissue repair. Unlike canonical FGFs, FGF12 belongs to the intracellular FGF11 subfamily (FGF11–14) that lacks secretory signals and functions independently of cell surface FGF receptors. Instead, it interacts with voltage-gated sodium channels (Nav) and other cytoplasmic targets, modulating neuronal excitability and cardiac electrophysiology. FGF12 is highly expressed in the brain, heart, and dorsal root ganglia, playing critical roles in nervous system development, synaptic plasticity, and cardiac rhythm maintenance.
FGF12 antibodies are essential tools for studying the protein's expression, localization, and functional mechanisms. They are widely used in techniques like immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to map FGF12 distribution in tissues or assess its levels in disease models. Research has linked FGF12 dysregulation to neurological disorders (e.g., epilepsy, neuropathic pain) and cardiac arrhythmias, making its antibodies valuable for exploring pathophysiological pathways. Recent studies also highlight FGF12's potential role in cancer progression, particularly in gliomas. However, challenges remain in distinguishing FGF12 isoforms (FGF12A, FGF12B) due to alternative splicing, necessitating isoform-specific antibody validation. Overall, FGF12 antibodies are pivotal in advancing both basic research and therapeutic targeting of FGF12-associated diseases.
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