| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | 30K, CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CAPNS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAPNS1抗体的3篇参考文献示例(文献信息为模拟概括，仅供参考)：
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1. **文献名称**：*CAPNS1 regulates autophagy via modulating calcium-dependent calpain activation in neurodegenerative models*
**作者**：Li, X., et al.
**摘要**：本研究利用CAPNS1特异性抗体，验证了CAPNS1通过调控钙蛋白酶活性影响自噬通路，揭示了其在阿尔茨海默病模型中神经元退行性变的作用机制。
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2. **文献名称**：*Targeting CAPNS1 as a therapeutic strategy in triple-negative breast cancer*
**作者**：Chen, Y., et al.
**摘要**：通过CAPNS1抗体检测发现，CAPNS1在三阴性乳腺癌中高表达，敲低CAPNS1可抑制肿瘤细胞迁移和侵袭，提示其作为潜在治疗靶点。
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3. **文献名称**：*CAPNS1 deficiency disrupts skeletal muscle development via impaired calpain signaling*
**作者**：Smith, J.R., et al.
**摘要**：利用CAPNS1敲除小鼠模型及抗体进行蛋白互作分析，证实CAPNS1缺失导致钙蛋白酶活性丧失，进而影响肌肉分化相关蛋白的剪切和功能。
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**注**：以上文献为示例性内容，实际引用时需以真实发表的论文为准。建议通过PubMed或Web of Science以“CAPNS1 antibody”或“calpain small subunit 1”为关键词检索最新研究。
The CAPNS1 antibody targets the regulatory subunit of the calpain system, a family of calcium-dependent cysteine proteases. CAPNS1 (also known as calpain small subunit 1) is essential for stabilizing and activating calpain heterodimers, which consist of a catalytic large subunit (e.g., CAPN1/CAPN2) and CAPNS1. Calpains play critical roles in calcium-mediated signaling pathways, influencing processes such as cell migration, apoptosis, cytoskeletal remodeling, and membrane repair. Dysregulation of calpain activity is linked to pathologies including cancer metastasis, neurodegenerative diseases, and muscular dystrophy.
CAPNS1 antibodies are widely used to study calpain expression, localization, and function in diverse biological contexts. These antibodies enable detection of CAPNS1 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also employ CAPNS1 antibodies to investigate calpain complex formation, activity regulation, and interactions with substrates or inhibitors. In disease models, CAPNS1 antibodies help elucidate calpain's role in tissue injury, inflammation, or tumor progression. Additionally, they serve as tools for validating genetic knockdown/knockout models or assessing therapeutic interventions targeting calpain pathways. High specificity and sensitivity are critical for these applications, given the ubiquitous expression of calpains and their tight regulation in cells.
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