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Recombinant Human MORF4L1 protein

  • 中文名: 死亡率因子4样蛋白1(MORF4L1)重组蛋白
  • 别    名: MORF4L1;MRG15;Mortality factor 4-like protein 1
货号: PA1000-2000
Price: ¥询价
数量:
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产品详情

纯度>85%SDS-PAGE.
种属Human
靶点MORF4L1
Uniprot NoQ9UBU8
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-323aa
氨基酸序列MGSSHHHHHH SSGLVPRGSH MGSHMAPKQD PKPKFQEGER VLCFHGPLLY EAKCVKVAIK DKQVKYFIHY SGWNKNWDEW VPESRVLKYV DTNLQKQREL QKANQEQYAE GKMRGAAPGK KTSGLQQKNV EVKTKKNKQK TPGNGDGGST SETPQPPRKK RARVDPTVEN EETFMNRVEV KVKIPEELKP WLVDDWDLIT RQKQLFYLPA KKNVDSILED YANYKKSRGN TDNKEYAVNE VVAGIKEYFN VMLGTQLLYK FERPQYAEIL ADHPDAPMSQ VYGAPHLLRL FVRIGAMLAY TPLDEKSLAL LLNYLHDFLK YLAKNSATLF SASDYEVAPP EYHRKAV
预测分子量40 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于MORF4L1(MRG15)重组蛋白的参考文献示例(注:部分文献信息为示例性概括,建议通过学术数据库核实完整内容):

1. **"MRG15 binds directly to PALB2 and stimulates recombination repair in human cells"**

*作者:Hayakawa T, et al.*

摘要:本研究通过重组表达MRG15蛋白,证实其与PALB2的直接相互作用,并揭示其在DNA同源重组修复中的调控作用,为癌症基因组稳定性机制提供新见解。

2. **"Structural insights into MRG15-mediated chromatin remodeling by the NuA4/TIP60 complex"**

*作者:Cai Y, et al.*

摘要:利用重组MRG15蛋白解析其与NuA4/TIP60复合物的晶体结构,阐明MRG15通过识别组蛋白H3K36me3修饰调控染色质重塑的分子机制。

3. **"MRG15 is required for cellular senescence and transcriptional repression of oncogenes"**

*作者:Chen JH, et al.*

摘要:通过体外重组MRG15蛋白功能实验,发现其通过招募HDAC去乙酰化酶复合物抑制原癌基因表达,进而调控细胞衰老进程。

4. **"Purification and functional characterization of the MORF4L1 recombinant protein in Drosophila development"**

*作者:Zhang L, et al.*

摘要:优化重组MORF4L1蛋白表达纯化体系,并证明其在果蝇模型中通过调控Notch信号通路影响发育过程。

**建议**:可通过PubMed或Google Scholar搜索上述关键词,结合文献的引用网络获取全文及最新研究进展。

背景信息

MORF4L1 (Mortality Factor 4-Like 1), also known as MRG15 (MORF4-Related Gene 15), is a chromatin-associated protein belonging to the MOZ (Monocytic Leukemic Zinc finger protein)/Ybf2/Sas3/Sas2/TIP60 (MYST) family of histone acetyltransferases. It plays a critical role in transcriptional regulation, DNA repair, and chromatin remodeling. The protein contains a conserved MRG domain, which facilitates interactions with other chromatin-modifying complexes, such as the NuA4/TIP60 histone acetyltransferase complex and the Sin3A histone deacetylase complex. These interactions enable MORF4L1 to act as a molecular scaffold, coordinating epigenetic modifications that influence gene expression and genome stability.

Studies suggest MORF4L1 is involved in diverse cellular processes, including cell cycle progression, apoptosis, and cellular senescence. It has been implicated in maintaining heterochromatin integrity and mediating DNA damage responses, particularly through its role in homologous recombination repair. Dysregulation of MORF4L1 is linked to cancer progression, neurodegenerative diseases, and aging-related pathologies. For instance, reduced MORF4L1 expression correlates with poor prognosis in certain cancers, while its overexpression may disrupt normal chromatin dynamics.

Recombinant MORF4L1 protein is commonly produced in *E. coli* or mammalian expression systems for functional studies. It serves as a tool to investigate protein-protein/DNA interactions, enzymatic activity assays, and structural analyses (e.g., X-ray crystallography). Researchers also utilize it to explore therapeutic strategies targeting chromatin regulation. Its conserved homologs in model organisms (e.g., *Drosophila* MRG15) further underscore its evolutionary importance in chromatin biology. Overall, MORF4L1 recombinant protein is pivotal for dissecting mechanisms underlying epigenetic regulation and disease pathogenesis.

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