Rabbit Polyclonal ENPP5 Antibody

The ENPP5 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 5) antibody is a tool used to detect and study the ENPP5 protein, a member of the ENPP family involved in hydrolyzing extracellular nucleotides like ATP and NAD. ENPP5. also termed PDNP5. is structurally characterized by a conserved catalytic domain and transmembrane regions, though its precise physiological role remains less defined compared to other ENPP members. It is highly expressed in the testes and brain, suggesting potential roles in reproductive and neurological processes. ENPP5 antibodies, typically monoclonal or polyclonal, are utilized in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate protein localization, expression patterns, and interactions. Research links ENPP5 to spermatogenesis and neuronal signaling, with studies exploring its involvement in male infertility and neurodegenerative conditions. Antibody validation, including knockout controls or siRNA knockdowns, ensures specificity for accurate experimental outcomes. While ENPP5's full functional scope is still emerging, its antibody serves as a critical reagent for elucidating its contributions to nucleotide metabolism, cellular communication, and disease pathways, highlighting its relevance in both basic and translational research contexts.