| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SCDO5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TBX6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TBX6抗体的3篇参考文献示例(注：部分信息为模拟虚构，仅作格式参考)：
1. **文献名称**: *TBX6 mutations and their role in congenital scoliosis: A genotype-phenotype study*
**作者**: Smith, J., et al.
**摘要**: 本研究利用TBX6特异性抗体进行免疫组织化学分析，发现TBX6蛋白在人类胚胎神经管和体节中高表达。通过基因测序和抗体检测，揭示了TBX6杂合突变与先天性脊柱侧凸的关联性。
2. **文献名称**: *Developmental regulation of Tbx6 in murine somitogenesis*
**作者**: Li, X., & Wang, Q.
**摘要**: 文章通过TBX6抗体在小鼠模型中的Western blot和免疫荧光实验，证实TBX6在体节前中胚层的动态表达模式，并阐明其通过调控Mesogenin 1参与体节分化的分子机制。
3. **文献名称**: *A novel TBX6 antibody-based ELISA assay for clinical diagnosis of CAKUT*
**作者**: Zhang, R., et al.
**摘要**: 研究开发了一种高特异性TBX6多克隆抗体，并基于此建立ELISA检测法，用于先天性肾脏和尿路畸形(CAKUT)患者的血清TBX6水平筛查，提示其作为潜在生物标志物的价值。
**备注**：若需真实文献，建议通过PubMed或Google Scholar检索关键词“TBX6 antibody”“TBX6 protein analysis”等，并筛选涉及抗体应用(如染色、检测、疾病模型)的研究。
The T-box transcription factor 6 (TBX6) is a member of the T-box gene family, which plays critical roles in embryonic development, particularly in somitogenesis, mesoderm specification, and organogenesis. TBX6 is highly conserved across vertebrates and is essential for the formation of paraxial mesoderm-derived structures, including the somites that give rise to skeletal muscle, vertebrae, and dermis. In humans, TBX6 mutations or deletions are linked to congenital vertebral malformations, such as congenital scoliosis, highlighting its importance in axial skeletal development.
TBX6 antibodies are immunological tools designed to detect and quantify TBX6 protein expression in research settings. These antibodies are typically generated using immunogenic peptides or recombinant protein fragments of TBX6 and are validated for applications like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. They enable the study of TBX6's spatial and temporal expression patterns during embryogenesis, its interaction with signaling pathways (e.g., Wnt/β-catenin or Notch), and its role in disease models. Specificity is a key consideration, as cross-reactivity with other T-box family members (e.g., TBX4 or TBX5) must be ruled out. TBX6 antibodies are also utilized in clinical research to explore genetic disorders associated with developmental defects, offering insights into molecular mechanisms and potential therapeutic targets.
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