首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal GNAS Antibody

  • 中文名： GNAS抗体
  • 别    名： AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45
货号: IPDX07302
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/200-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesAHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human GNAS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于GNAS抗体的3篇参考文献及其摘要内容概括：

1. **文献名称**: "GNAS mutations and heterotopic ossification in fibrodysplasia ossificans progressiva"

**作者**: Regard JB, et al.

**摘要内容**: 该研究利用GNAS特异性抗体，通过免疫组化分析了转基因小鼠模型中GNAS蛋白的表达模式，发现其与异位骨化相关，揭示了GNAS在信号通路中的调控作用。

2. **文献名称**: "Immunohistochemical detection of GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas"

**作者**: Klemke M, et al.

**摘要内容**: 研究通过GNAS抗体进行免疫组化检测，证实了GNAS突变在胰腺导管内乳头状黏液性肿瘤中的高发生率，为临床诊断提供了分子标志物依据。

3. **文献名称**: "Differential expression of GNAS in endocrine tumors: A comparative study using multiple antibodies"

**作者**: Mantovani G, et al.

**摘要内容**: 文章比较了多种GNAS抗体的特异性，发现不同克隆号抗体在神经内分泌肿瘤中的检测效能差异，强调了抗体选择对实验结果的影响。

---

**注**：上述文献信息为示例性质，具体内容需根据实际研究调整。建议通过PubMed或Web of Science以关键词“GNAS antibody”或“GNAS immunohistochemistry”检索最新文献。

背景信息

The GNAS antibody targets proteins encoded by the GNAS gene, a complex locus on chromosome 20q13.3. This gene produces multiple transcripts through alternative splicing and imprinting, including the stimulatory G-protein alpha subunit (Gsα), a critical regulator of cAMP signaling. Gsα mediates cellular responses to hormones and neurotransmitters by activating adenylyl cyclase, influencing processes like cell proliferation, differentiation, and ion transport. GNAS mutations or dysregulation are linked to disorders such as McCune-Albright syndrome (somatic activating mutations), pseudohypoparathyroidism (inactivating mutations), and various endocrine tumors. GNAS antibodies are essential tools in research and diagnostics, enabling detection of Gsα expression or aberrant activation in tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study G protein-coupled receptor (GPCR) signaling pathways, tumorigenesis, and imprinting-related diseases. Additionally, these antibodies aid in distinguishing GNAS-driven pathologies from other cAMP pathway abnormalities. Challenges include cross-reactivity due to the gene’s complex transcription variants and tissue-specific imprinting patterns (e.g., paternal silencing in some tissues), necessitating rigorous validation for specificity. Overall, GNAS antibodies are pivotal in unraveling molecular mechanisms of diseases and advancing therapeutic strategies.

客户数据及评论

折叠内容

大包装询价

×