Rabbit Polyclonal GNB1 Antibody

The GNB1 antibody targets the beta-1 subunit of heterotrimeric G proteins, which are critical mediators of intracellular signaling. GNB1 encodes the β1 subunit, a component of the Gβγ complex that partners with Gα subunits to regulate downstream effectors like adenylyl cyclase, ion channels, and MAP kinases. These proteins are involved in diverse cellular processes, including cell growth, differentiation, and neurotransmitter signaling. Antibodies against GNB1 are widely used in research to study G protein-coupled receptor (GPCR) pathways, protein-protein interactions, and subcellular localization of Gβγ complexes. They are essential tools in techniques such as Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of GNB1 has been implicated in diseases, including cancers and neurodevelopmental disorders. For example, somatic mutations in GNB1 are linked to hematologic malignancies, while germline variants are associated with developmental delays and autism spectrum disorders. Studying GNB1 expression and function using specific antibodies helps elucidate its role in both normal physiology and disease mechanisms, offering potential insights for therapeutic targeting.