| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | GMR, CD116, CSF2R, SMDP4, CDw116, CSF2RX, CSF2RY, GMCSFR, CSF2RAX, CSF2RAY, GM-CSF-R-alpha |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CSF2RA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSF2RA抗体的模拟参考文献示例(实际文献需根据具体研究验证)：
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1. **文献名称**: *Autoantibodies against CSF2RA in systemic lupus erythematosus: Pathogenic implications*
**作者**: Tanaka M, et al.
**摘要**: 研究报道了系统性红斑狼疮(SLE)患者血清中存在的抗CSF2RA自身抗体，发现其通过阻断GM-CSF信号通路抑制单核细胞分化，可能与SLE的免疫失调相关。
2. **文献名称**: *CSF2RA gene expression regulated by epigenetic modifications in autoimmune disorders*
**作者**: Zhang L, et al.
**摘要**: 分析CSF2RA基因在类风湿关节炎中的表达异常，揭示DNA甲基化修饰影响其转录水平，并验证抗CSF2RA抗体对下游JAK-STAT通路的抑制作用。
3. **文献名称**: *CSF2RA as a potential biomarker for primary biliary cholangitis*
**作者**: Hirschfield GM, et al.
**摘要**: 提出抗CSF2RA抗体在原发性胆汁性胆管炎(PBC)患者中的特异性表达，其滴度与疾病活动度正相关，或可作为新型诊断标志物。
4. **文献名称**: *Functional characterization of anti-CSF2RA antibodies in reproductive failure*
**作者**: Alijotas-Reig J, et al.
**摘要**: 探讨抗CSF2RA抗体与复发性流产的关联，实验表明其通过干扰胎盘滋养层细胞的GM-CSF依赖性增殖，影响胚胎着床过程。
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**注意**：以上文献为示例性内容，实际研究中需通过PubMed/Google Scholar等平台检索真实文献，并核对作者及摘要准确性。
The CSF2RA (Colony Stimulating Factor 2 Receptor Subunit Alpha) antibody targets the alpha subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor, a key player in hematopoietic cell regulation. The CSF2RA gene, located in the pseudoautosomal region of X and Y chromosomes, encodes a cytokine receptor critical for binding GM-CSF, initiating downstream signaling pathways like JAK/STAT, and promoting the proliferation, differentiation, and functional activation of macrophages, neutrophils, and dendritic cells.
CSF2RA antibodies are essential tools in studying receptor expression, signaling mechanisms, and dysregulation in diseases. For instance, reduced CSF2RA function is linked to hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disorder caused by impaired GM-CSF signaling and surfactant clearance. Antibodies against CSF2RA enable detection of receptor levels in tissues or cells via techniques like flow cytometry, Western blotting, or immunohistochemistry, aiding in diagnostics and research. They also help investigate autoimmune conditions or cancers where aberrant GM-CSF signaling may contribute to pathogenesis. Additionally, CSF2RA antibodies are used in preclinical models to explore therapeutic strategies targeting this pathway, such as modulating immune responses or addressing receptor deficiencies. Their specificity ensures precise analysis of CSF2RA's role in both physiological and pathological contexts.
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