Rabbit Polyclonal GDF9 Antibody

GDF9 (Growth Differentiation Factor 9), a member of the TGF-β superfamily, is a critical oocyte-secreted protein regulating folliculogenesis and female fertility. It plays a pivotal role in ovarian function, including oocyte maturation, cumulus cell expansion, and granulosa cell proliferation. GDF9 antibodies are immunological tools designed to detect, quantify, or neutralize GDF9 protein in research and clinical contexts. These antibodies, often polyclonal or monoclonal, are generated by immunizing host animals with purified GDF9 peptides or recombinant proteins. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study GDF9 expression patterns in ovarian tissues, follicular fluid, or serum. Given GDF9's association with reproductive disorders such as primary ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS), specific antibodies aid in investigating disease mechanisms and potential biomarkers. Additionally, neutralizing GDF9 antibodies have been explored in animal studies to modulate follicular development, providing insights into contraceptive strategies or fertility treatments. Validation of antibody specificity remains crucial due to structural similarities among TGF-β family members. Recent studies also highlight GDF9's extrapituitary roles in metabolic regulation, expanding the antibody's applications beyond reproductive biology.