| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HL14 |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LGALS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及LGALS2(galectin-2)抗体的相关文献摘要：
1. **文献名称**: *"Galectin-2 modulates immune responses by regulating T-cell apoptosis"*
**作者**: Sato S, et al.
**摘要**: 本研究利用抗LGALS2抗体探究galectin-2在T细胞凋亡中的作用，发现其通过结合CD29(β1整合素)调控T细胞存活，影响炎症反应及自身免疫疾病发展。
2. **文献名称**: *"LGALS2 antibody inhibits atherosclerosis by targeting macrophage polarization"*
**作者**: Chen L, et al.
**摘要**: 通过抗LGALS2抗体阻断galectin-2功能，发现其可抑制巨噬细胞向促炎表型极化，减少动脉粥样硬化斑块形成，为心血管疾病治疗提供潜在靶点。
3. **文献名称**: *"Galectin-2 as a biomarker for inflammatory bowel disease: A monoclonal antibody-based detection approach"*
**作者**: Kimura H, et al.
**摘要**: 研究开发了高特异性抗LGALS2单克隆抗体，证实galectin-2在炎症性肠病患者血清中显著升高，提示其作为疾病诊断生物标志物的潜力。
4. **文献名称**: *"Antibody-mediated targeting of galectin-2 in cancer immunotherapy"*
**作者**: Wang Y, et al.
**摘要**: 利用抗LGALS2抗体阻断galectin-2与肿瘤微环境中免疫细胞的相互作用，增强抗肿瘤免疫应答，为癌症免疫治疗提供新策略。
(注：上述文献为示例性内容，实际文献需通过PubMed或Google Scholar检索关键词“LGALS2 antibody”、“galectin-2 antibody”获取。)
**Background of LGALS2 Antibody**
The LGALS2 antibody targets the protein galectin-2. encoded by the *LGALS2* gene, a member of the galectin family known for binding β-galactoside sugars via conserved carbohydrate recognition domains. Galectin-2 is a small, homodimeric lectin expressed in various tissues, including the gastrointestinal tract, immune cells, and vascular endothelium. It plays roles in inflammation, apoptosis, and immune regulation by interacting with ligands such as lymphotoxin-α, influencing pathways like NF-κB signaling.
Research highlights LGALS2's association with cardiovascular diseases, particularly myocardial infarction, where specific polymorphisms may modulate disease risk. It is also implicated in autoimmune disorders and cancer progression, potentially affecting tumor immunity and metastasis.
LGALS2 antibodies are essential tools for detecting galectin-2 expression and localization in experimental models, using techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies aid in studying galectin-2's functional mechanisms, its interaction with cellular components, and its diagnostic or therapeutic potential. Commercial LGALS2 antibodies are typically validated for specificity and cross-reactivity across species (e.g., human, mouse), supporting translational research in disease biomarkers and molecular pathways.
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