| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CMF608 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IGSF10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGSF10抗体的模拟参考文献示例(供参考，实际文献请通过学术数据库检索)：
1. **标题**: "IGSF10 regulates spermatogenesis through Sertoli cell-spermatid adhesion in mice"
**作者**: Li, X., et al.
**摘要**: 本研究利用IGSF10特异性抗体，揭示了IGSF10蛋白在小鼠睾丸支持细胞中的高表达，并通过免疫共沉淀证明其参与精子发生过程中细胞间黏附的关键作用。
2. **标题**: "IGSF10 antibody-based detection reveals its tumor-suppressive role in colorectal cancer"
**作者**: Wang, Y., et al.
**摘要**: 通过免疫组化和Western blot分析，发现IGSF10在结直肠癌组织中表达下调，其抗体阻断实验表明IGSF10可通过抑制Wnt/β-catenin通路延缓肿瘤进展。
3. **标题**: "Structural characterization of IGSF10 extracellular domains using monoclonal antibodies"
**作者**: Tanaka, K., et al.
**摘要**: 研究开发了针对IGSF10胞外结构域的单克隆抗体，结合冷冻电镜技术解析了IGSF10的构象变化，揭示了其在神经元突触形成中的潜在机制。
4. **标题**: "IGSF10 deficiency disrupts embryonic brain development: Evidence from antibody-mediated knockdown models"
**作者**: Chen, L., et al.
**摘要**: 利用IGSF10中和抗体在斑马鱼模型中干扰其功能，发现IGSF10缺失导致神经管闭合异常，提示其在胚胎神经系统发育中的必要性。
**注意**：以上为模拟摘要，真实文献请通过PubMed、Google Scholar等平台以“IGSF10 antibody”或“IGSF10 function”为关键词检索。
**Background of IGSF10 Antibodies**
The immunoglobulin superfamily member 10 (IGSF10) is a transmembrane protein belonging to the immunoglobulin superfamily, which plays roles in cell adhesion, signaling, and development. IGSF10 is notably involved in regulating cellular processes such as neuronal development, reproductive system function, and tissue morphogenesis. Studies suggest its association with congenital disorders, including hypogonadotropic hypogonadism and defects in brain connectivity.
IGSF10 antibodies are immunological tools designed to detect and study the expression, localization, and function of the IGSF10 protein. These antibodies are typically developed using immunogenic regions of IGSF10. such as its extracellular immunoglobulin domains or cytoplasmic regions, and are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence.
Research utilizing IGSF10 antibodies has highlighted its expression in tissues like the brain, testes, and developing organs, supporting its role in neuroendocrine and reproductive biology. Dysregulation of IGSF10 has been linked to developmental anomalies, making these antibodies valuable for investigating molecular mechanisms in disease models. Commercial IGSF10 antibodies are often characterized for specificity and cross-reactivity across species, aiding translational research. Ongoing studies aim to clarify its interactions with signaling pathways and potential therapeutic targets.
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