| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ING1L; p33ING2 |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ING2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ING2抗体相关的参考文献，按研究主题和内容简要概括：
1. **"ING2 regulates chromatin structure and gene expression by modulating histone H3K4 methylation"**
*作者：Garkavtsev et al. (2004)*
**摘要**：研究揭示了ING2通过结合组蛋白H3K4me3并招募组蛋白去乙酰化酶(HDAC)复合体，调控染色质结构和基因表达的功能。实验使用ING2抗体进行免疫沉淀和染色质免疫共沉淀(ChIP)，证实其在抑制肿瘤生长中的关键作用。
2. **"The tumor suppressor ING2 mediates epigenetic regulation of cellular senescence"**
*作者：Thalappilly et al. (2010)*
**摘要**：通过免疫组织化学(IHC)和Western blot分析，研究证明ING2抗体检测到的蛋白表达水平与细胞衰老和DNA损伤修复相关。ING2缺失导致表观遗传修饰异常，促进肿瘤发生。
3. **"ING2 interacts with p300/CBP to enhance p53 acetylation and transcriptional activity"**
*作者：Kuo et al. (2008)*
**摘要**：文章利用ING2抗体进行共聚焦显微成像和免疫共沉淀实验，发现ING2通过结合p300/CBP复合体增强p53的乙酰化，进而激活促凋亡基因，抑制肿瘤进展。
4. **"Loss of ING2 expression predicts poor prognosis in hepatocellular carcinoma"**
*作者：Unoki et al. (2011)*
**摘要**：临床样本分析中，ING2抗体的免疫组化结果显示，ING2低表达与肝癌患者生存率下降显著相关，提示其作为预后生物标志物的潜力。
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**备注**：以上文献标题和作者为模拟示例，实际引用需以真实出版物为准。建议通过PubMed或Google Scholar以关键词“ING2 antibody”、“ING2 function”或“ING2 cancer”检索最新研究。
The ING2 (Inhibitor of Growth 2) antibody is a research tool used to detect and study the ING2 protein, a member of the ING family of tumor suppressors. ING2 is a nuclear protein involved in chromatin remodeling, transcriptional regulation, and cellular stress responses. It interacts with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes, modulating histone acetylation status to influence gene expression. ING2 plays roles in cell cycle arrest, apoptosis, DNA repair, and senescence, often acting as a tumor suppressor by regulating p53-dependent pathways. Dysregulation of ING2 has been linked to cancers, neurodegenerative diseases, and aging.
The ING2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in cell lines or tissues. Researchers utilize it to explore ING2's involvement in epigenetic regulation, cancer progression, and therapeutic responses. Specificity and validation (e.g., knockout controls) are critical due to potential cross-reactivity with other ING family members. Commercial antibodies often target epitopes within the N-terminal region or plant homeodomain (PHD) zinc finger, which are essential for ING2's chromatin-binding activity. Studies employing this antibody have revealed ING2's downregulation in certain malignancies and its role in oxidative stress responses, making it a focal point in both basic and translational cancer research.
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