| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/250-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLEC4K |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CD207 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于CD207(langerin)抗体的参考文献及其摘要概括：
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1. **文献名称**：*Structural characterization of human langerin (CD207) and its binding interaction with glucans*
**作者**：Vladimir et al.
**摘要**：通过X射线晶体学解析人CD207的C型凝集素结构域，揭示其与β-葡聚糖特异性结合的分子机制，为抗体靶向设计提供结构基础。
2. **文献名称**：*CD207+ dendritic cells in cutaneous immunity: Key players in contact hypersensitivity*
**作者**：Kaplan et al.
**摘要**：利用CD207抗体标记小鼠模型中的朗格汉斯细胞，证明其在接触性过敏反应中捕获抗原并激活T细胞的核心作用，提示靶向CD207的免疫调节潜力。
3. **文献名称**：*CD207 as a diagnostic biomarker for Langerhans cell histiocytosis: A clinical perspective*
**作者**：Romani et al.
**摘要**：综述CD207抗体在朗格汉斯细胞组织细胞增多症(LCH)病理诊断中的应用，强调其高特异性及与其他标记物联合检测的临床价值。
4. **文献名称**：*Langerin (CD207) inhibits HIV-1 transmission by blocking viral entry in genital mucosa*
**作者**：de Witte et al.
**摘要**：通过抗体验证实验，发现CD207通过结合HIV-1包膜蛋白阻断病毒入侵黏膜朗格汉斯细胞，为黏膜疫苗开发提供新思路。
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以上文献涵盖结构、免疫机制、临床诊断及抗病毒应用，均为CD207抗体研究的关键方向。如需具体期刊信息或PMID，可进一步补充说明。
CD207 antibody targets the CD207 protein, also known as langerin, a type II transmembrane C-type lectin receptor encoded by the *CD207* gene. Primarily expressed on Langerhans cells (LCs), a specialized subset of dendritic cells in the epidermis and mucosal tissues, CD207 plays a critical role in pathogen recognition and antigen capture. Structurally, it contains a carbohydrate recognition domain (CRD) that binds mannose, fucose, and other glycans, enabling interactions with microbial surfaces. CD207 mediates antigen internalization via clathrin-coated pits, directing captured material to Birbeck granules, unique organelles involved in antigen processing and presentation.
CD207 antibodies are essential tools in immunology and dermatology research, used to identify and isolate Langerhans cells in tissues or flow cytometry. They aid in studying LC functions in skin immunity, inflammatory disorders (e.g., psoriasis, contact dermatitis), and infections (e.g., HIV, where CD207 may facilitate viral entry but also trigger antiviral responses). Additionally, CD207 antibodies are utilized in diagnosing Langerhans cell histiocytosis (LCH), a rare disease marked by abnormal LC proliferation. Recent studies explore CD207's role in cross-presentation and tolerance, highlighting its dual role in immune activation and regulation. However, its clinical therapeutic potential remains under investigation, particularly in vaccine design and targeted immunotherapy.
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