| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | M40; TUBB1; TUBB5; CDCBM6; CSCSC1; OK/SW-cl.56 |
| Entrez GeneID | 203068 |
| clone | 4D4G6 |
| WB Predicted band size | 50.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Loading Control Antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Monkey |
| Immunogen | Purified recombinant fragment of human TUBB1 (AA: 1-444) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SERPINB5(maspin)抗体的3篇参考文献及其摘要概述：
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1. **文献名称**: "Maspin expression in human breast cancer: Immunohistochemical analysis using a monoclonal antibody"
**作者**: Zou Z 等
**摘要内容**: 该研究利用特异性单克隆抗体，通过免疫组化技术分析乳腺癌组织中maspin(SERPINB5)的表达水平，发现其在正常乳腺组织与癌变组织中的差异表达，提示其可能作为肿瘤抑制标志物。
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2. **文献名称**: "SERPINB5/maspin is a predictive biomarker for therapeutic response in pancreatic cancer"
**作者**: Pemberton PA 等
**摘要内容**: 通过Western blot和免疫荧光技术，研究团队使用SERPINB5抗体检测胰腺癌患者样本，发现高maspin表达与化疗敏感性相关，表明其可能作为治疗反应的预测因子。
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3. **文献名称**: "Role of SERPINB5 in epithelial-mesenchymal transition and tumor invasion"
**作者**: Lockett J 等
**摘要内容**: 该研究采用SERPINB5抗体进行体外细胞实验，证明maspin通过调控上皮-间质转化(EMT)抑制肿瘤侵袭，为靶向治疗提供了潜在分子机制依据。
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以上文献均涉及SERPINB5抗体的实验应用(如免疫组化、Western blot等)，并探讨其在癌症生物学中的功能及临床意义。
SERPINB5. also known as maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor (serpin) superfamily. Unlike most serpins, it lacks conventional protease inhibitory activity but plays complex roles in cellular processes, including tumor suppression. It is encoded by the SERPINB5 gene and is primarily expressed in epithelial cells. Research highlights its dual role in cancer biology, acting as a tumor suppressor by inhibiting cell invasion, metastasis, and angiogenesis in cancers like breast, prostate, and pancreatic cancer, while paradoxically showing pro-tumor effects in certain contexts.
SERPINB5 antibodies are critical tools for detecting and quantifying SERPINB5 protein expression in research and diagnostics. These antibodies enable the study of its subcellular localization (e.g., nuclear vs. cytoplasmic distribution), expression patterns in normal vs. tumor tissues, and its interaction partners. Commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), they help elucidate SERPINB5's controversial mechanisms, which may involve regulation of extracellular matrix remodeling, apoptosis, and epigenetic modulation. Discrepancies in clinical studies regarding its prognostic value emphasize the importance of antibody specificity and validation. Reliable SERPINB5 antibodies are vital for exploring its therapeutic potential and biomarker utility in cancer.
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