Rabbit Polyclonal NGB Antibody

Neuroglobin (NGB) is a member of the globin family, primarily expressed in vertebrate nervous systems, including the brain and retina. Discovered in 2000. it binds oxygen with high affinity and is implicated in neuroprotection under hypoxic or oxidative stress. Unlike hemoglobin or myoglobin, NGB is localized in neurons and some endocrine cells, suggesting specialized roles in oxygen homeostasis, cellular metabolism, and redox signaling. NGB antibodies are essential tools for detecting and studying this protein’s expression, distribution, and function. They enable researchers to explore NGB’s involvement in mitigating neuronal damage during ischemic stroke, traumatic brain injury, and neurodegenerative disorders like Alzheimer’s disease. Commercially available NGB antibodies are typically raised against specific epitopes of human or rodent NGB, validated for techniques such as Western blotting, immunohistochemistry, and ELISA. Recent studies highlight NGB’s potential as a biomarker for neurological conditions and a therapeutic target. However, challenges remain in standardizing antibody specificity due to NGB’s structural similarities with other globins. Ongoing research aims to clarify its molecular mechanisms, including interactions with mitochondrial pathways and nitric oxide scavenging. NGB antibodies thus remain critical in advancing both basic neuroscience and clinical applications targeting neuroprotection.