关键信息
-
基因名
Syntenin-1
-
简介
Syntenin-1 is a multifunctional adapter protein that coordinates multiple cellular processes, including transmembrane protein trafficking, neural and immune regulation, exosome biogenesis, and tumorigenesis. It actively regulates TGFB1 signaling and enhances SMAD2/3 activation, TGFB1-induced epithelial-mesenchymal transition (EMT), and cell migration. Syntenin-1 Protein, Human (C-His) is the recombinant human-derived Syntenin-1 protein, expressed by E. coli , with C-6*His labeled tag.
- 应用
-
别名
Syntenin-1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP; MDA9; SYCL;
-
种属
Human
-
表达系统
E. coli
-
标签
C-6*His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O00560
-
表达区间
S2-V298
-
氨基酸序列
SLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
-
蛋白长度
Full Length
-
分子量
32.0 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Syntenin-1 is a multifunctional protein that plays a pivotal role in various cellular processes, including signal transduction, endosomal sorting, and cytoskeletal dynamics. It functions as an adaptor protein, linking various signaling pathways to the endosomal compartments and facilitating the transport of cargo within the cell. Research has shown that Syntenin-1 interacts with multiple binding partners, which suggests its involvement in diverse biological processes such as cancer progression, cell migration, and immune responses. The interest in Syntenin-1 has been fueled by its potential as a therapeutic target, particularly in cancers where its expression levels are altered. The recombinant production of Syntenin-1 allows for in-depth studies on its structural and functional properties, enabling researchers to explore its role in pathophysiological conditions. By generating Syntenin-1 as a recombinant protein, scientists can investigate its interactions with other proteins and its downstream effects on cellular functions, thereby shedding light on its contributions to disease mechanisms. Moreover, understanding the biophysical characteristics of Syntenin-1 can inform drug design strategies aimed at modulating its activity. Overall, the study of recombinant Syntenin-1 represents a promising avenue for elucidating its biological roles and identifying potential interventions in diseases associated with its dysregulation.
