| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NDK 6; NM23-H6; IPIA-ALPHA |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NME6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于NME6抗体的文献摘要概括(文献为虚拟示例，仅作格式参考)：
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1. **文献名称**: *NME6 regulates mitochondrial dynamics and apoptosis via interaction with Drp1*
**作者**: Chen L, et al.
**摘要**: 本研究利用特异性NME6抗体，通过免疫共沉淀和Western blot技术，揭示了NME6通过结合线粒体分裂蛋白Drp1调控线粒体形态和细胞凋亡的分子机制，为神经退行性疾病研究提供新靶点。
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2. **文献名称**: *Development of a novel monoclonal antibody against human NME6 for cancer biomarker studies*
**作者**: Kim S, et al.
**摘要**: 文章报道了一种高特异性小鼠源单克隆NME6抗体的开发，验证其在乳腺癌组织中的免疫组化应用，并发现NME6表达水平与肿瘤转移呈负相关，提示其潜在诊断价值。
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3. **文献名称**: *NME6 interacts with c-Myc to modulate transcriptional activity in hepatocellular carcinoma*
**作者**: Wang Y, et al.
**摘要**: 通过NME6抗体的染色质免疫沉淀(ChIP)分析，发现NME6与c-Myc蛋白结合并增强其在肝癌细胞中的转录调控功能，表明NME6可能通过表观遗传机制促进肿瘤进展。
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注：以上文献为模拟内容，实际研究需通过PubMed或Google Scholar检索关键词“NME6 antibody”或“NME6 function”获取真实文献。
**Background of NME6 Antibody**
The NME6 (non-metastatic protein 6) antibody is a tool used to detect and study the NME6 protein, a member of the NME/NM23 family of nucleoside diphosphate kinases (NDPKs). This evolutionarily conserved family regulates nucleotide metabolism by catalyzing the transfer of phosphate groups between nucleoside triphosphates and diphosphates. NME6. also termed NDK6 or Nm23-H6. is localized to mitochondria and nuclei, suggesting roles in cellular energy homeostasis, mitochondrial dynamics, and nuclear processes.
NME6 is implicated in diverse cellular functions, including apoptosis, autophagy, and DNA repair. Studies link it to mitochondrial network maintenance and interactions with proteins like Drp1. which governs mitochondrial fission. Dysregulation of NME6 has been explored in cancer, neurodegenerative disorders, and metabolic diseases, though its precise mechanisms remain under investigation.
The NME6 antibody is critical for applications like Western blotting, immunofluorescence, and immunohistochemistry, enabling researchers to analyze protein expression, localization, and interactions. It aids in elucidating NME6's biological significance, particularly its dual role in mitochondrial and nuclear pathways, and its potential as a biomarker or therapeutic target. Commercial NME6 antibodies are typically validated for specificity and sensitivity across human and model organisms.
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