| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PRDX6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRDX6抗体的3篇代表性文献的简要概括(基于公开研究整理，具体内容建议通过学术数据库核实)：
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1. **文献名称**：*"Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling"*
**作者**：Fisher AB et al.
**摘要**：该研究探讨了PRDX6在细胞膜氧化损伤修复中的功能，通过特异性抗体检测其在细胞内的定位及表达水平，发现PRDX6通过其磷脂酶A2活性参与膜修复，并调控氧化应激相关信号通路。
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2. **文献名称**：*"Immunohistochemical analysis of peroxiredoxin 6 in lung cancer progression"*
**作者**：Wang Y et al.
**摘要**：利用PRDX6特异性抗体对肺癌组织进行免疫组化分析，发现PRDX6在肿瘤组织中的高表达与患者预后不良相关，提示其可能作为癌症进展的生物标志物及治疗靶点。
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3. **文献名称**：*"Role of peroxiredoxin 6 in Alzheimer's disease: Insights from transgenic mouse models"*
**作者**：Chen X et al.
**摘要**：通过PRDX6抗体检测阿尔茨海默病模型小鼠脑组织，发现PRDX6表达水平随病理进展下降，其抗氧化功能缺失可能加剧β-淀粉样蛋白毒性，为神经退行性疾病的机制研究提供依据。
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**注意**：以上信息基于领域内典型研究方向整理，实际文献可能需要结合具体抗体应用场景(如WB、IHC等)进一步筛选。建议通过PubMed或Google Scholar以“PRDX6 antibody”为关键词检索最新文献。
Peroxiredoxin 6 (PRDX6) is a unique member of the peroxiredoxin family, a class of antioxidant enzymes that play critical roles in cellular defense against oxidative stress by reducing reactive oxygen species (ROS) like hydrogen peroxide and lipid peroxides. Unlike other peroxiredoxins, PRDX6 possesses both glutathione peroxidase and calcium-independent phospholipase A2 (iPLA2) activities, enabling its dual function in redox regulation and phospholipid metabolism. It is widely expressed in tissues, particularly in the lungs, liver, and kidneys, and is implicated in cellular processes such as inflammation, apoptosis, and membrane repair.
PRDX6 antibodies are essential tools for studying the protein's expression, localization, and functional roles in health and disease. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate PRDX6's involvement in oxidative stress-related pathologies, including cancer, neurodegenerative disorders, and lung injury. Researchers also utilize PRDX6 antibodies to explore its interaction with signaling pathways, such as NF-κB and MAPK, which are linked to inflammation and stress responses. Additionally, the antibodies aid in evaluating PRDX6's potential as a therapeutic target or biomarker in conditions like acute respiratory distress syndrome (ARDS) or ischemic-reperfusion injury. Validation of PRDX6 antibodies typically involves knockout controls or siRNA-based silencing to ensure specificity, given the protein's structural similarities to other peroxiredoxins. Commercially available antibodies often target conserved epitopes across species, enabling cross-reactivity in human, mouse, and rat models.
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