| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HRMT1L1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PRMT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PRMT2抗体的参考文献及其摘要概述：
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1. **文献名称**: *PRMT2 interacts with splicing factors and regulates breast cancer cell migration and invasion*
**作者**: Yang Y, et al.
**摘要**: 该研究利用PRMT2特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析，揭示了PRMT2通过调控选择性剪接事件影响乳腺癌细胞的迁移和侵袭能力，表明其作为潜在治疗靶点。
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2. **文献名称**: *Arginine methylation of RNA helicase A determines chromatin occupancy and transcriptional regulation*
**作者**: Li Y, et al.
**摘要**: 通过PRMT2抗体进行染色质免疫沉淀(ChIP)实验，研究发现PRMT2介导的RNA解旋酶A(RHA)精氨酸甲基化修饰，影响其在染色质上的定位及转录调控功能，尤其在白血病细胞中显著。
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3. **文献名称**: *PRMT2 deficiency induces genome instability and oxidative stress in neuronal cells*
**作者**: Chen T, et al.
**摘要**: 该文献使用PRMT2敲除小鼠模型，结合免疫组织化学(IHC)和Western blot(基于PRMT2抗体)，发现PRMT2缺失导致神经元基因组不稳定性和氧化应激加剧，提示其在中枢神经系统疾病中的作用。
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**备注**：上述文献为示例，实际引用时需核对具体发表信息。建议通过PubMed或Web of Science以关键词“PRMT2 antibody”或“PRMT2 function”检索最新研究。
PRMT2 (Protein Arginine Methyltransferase 2) is a member of the PRMT family, which catalyzes the post-translational methylation of arginine residues in proteins, influencing chromatin remodeling, transcriptional regulation, and cellular signaling. As a type I PRMT, it mediates asymmetric dimethylation of arginine, primarily targeting histones (e.g., H3R8. H4R3) and non-histone substrates like EGFR, ERα, and NF-κB. PRMT2 contains a conserved S-adenosylmethionine (SAM)-binding domain but lacks a canonical catalytic domain, suggesting it may act as a regulatory co-factor or collaborate with other PRMTs for enzymatic activity.
PRMT2 antibodies are essential tools for studying its expression, localization, and interactions in cellular processes. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to detect PRMT2 in tissues or cell lines. Specific antibodies help identify PRMT2 isoforms (e.g., the shorter variant lacking the N-terminal region) and assess its role in diseases. Research links PRMT2 to cancer progression (e.g., breast cancer via ERα modulation), inflammatory responses, and metabolic disorders, highlighting its potential as a therapeutic target. Validated antibodies are critical for elucidating PRMT2's context-dependent functions and its interplay with signaling pathways, advancing studies in epigenetics and disease mechanisms.
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