| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RAMP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是我根据学术文献结构模拟的3篇关于RAMP3抗体的示例参考文献(注：以下为虚构示例，实际文献需通过PubMed/Google Scholar等平台查询)：
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1. **文献名称**: "Development and Characterization of a Novel Monoclonal Antibody for Human RAMP3"
**作者**: Tanaka K, et al.
**摘要**: 本研究开发了一种针对人源RAMP3蛋白的高特异性单克隆抗体，验证了其在Western blot、免疫组化中的有效性，并证实其可特异性识别RAMP3与CLR(降钙素受体样受体)的复合物，为研究肾上腺髓质素受体功能提供工具。
2. **文献名称**: "RAMP3 Antibody Reveals Distinct Expression Patterns in Cardiovascular Diseases"
**作者**: Smith JL, et al.
**摘要**: 通过免疫荧光和流式细胞术，利用RAMP3抗体发现其在动脉粥样硬化模型中内皮细胞表达显著上调，提示RAMP3可能通过调节血管平滑肌细胞迁移参与病理过程。
3. **文献名称**: "RAMP3-Mediated Signalling in Cancer Progression: Insights from Antibody-Based Inhibition"
**作者**: Chen H, et al.
**摘要**: 采用抗RAMP3中和抗体阻断肿瘤微环境中RAMP3/CLR通路，发现可抑制乳腺癌细胞侵袭转移，表明靶向RAMP3可能成为癌症治疗的潜在策略。
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建议通过以下途径获取真实文献：
1. **PubMed**: 搜索关键词 "RAMP3 antibody" 或 "RAMP3 immunohistochemistry"
2. **抗体公司官网**: 如Abcam、Santa Cruz等提供的抗体产品页面常附引用文献
3. **领域综述**: 检索 "RAMP3 and disease" 类综述，追踪其引用的原始研究。
The Receptor Activity-Modifying Protein 3 (RAMP3) is a member of the RAMP family, which comprises three transmembrane proteins (RAMP1-3) that modulate the trafficking and ligand specificity of G protein-coupled receptors (GPCRs), particularly the calcitonin receptor-like receptor (CALCRL). RAMP3 forms heterodimers with CALCRL to create functional receptors for peptides like adrenomedullin (AM) and calcitonin gene-related peptide (CGRP), influencing cardiovascular, metabolic, and inflammatory processes. RAMP3 is broadly expressed in tissues, including the vasculature, kidneys, and brain, and has been implicated in pathophysiological conditions such as hypertension, heart failure, cancer progression, and metabolic disorders.
RAMP3 antibodies are essential tools for detecting and studying RAMP3 expression, localization, and interaction with partner receptors. These antibodies enable research into RAMP3's role in receptor signaling dynamics, disease mechanisms, and therapeutic targeting. For example, studies suggest RAMP3 may promote tumor angiogenesis or regulate blood pressure via AM receptor activation. Validated RAMP3 antibodies are critical for techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation, ensuring specificity for distinguishing RAMP3 from other RAMPs. Recent research also explores RAMP3's dual roles in protective and pathogenic contexts, highlighting its potential as a biomarker or drug target. The development of high-affinity RAMP3 antibodies continues to advance understanding of its complex biology in health and disease.
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