| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | RAMP4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SERP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERP1抗体的参考文献示例(注：以下内容为模拟虚构，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of a Novel Monoclonal Antibody Against SERP1 for Detecting Endoplasmic Reticulum Stress in Neurodegenerative Models"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对SERP1蛋白的单克隆抗体，并验证其在Western blot和免疫组化中的应用。实验表明，该抗体特异性识别内质网应激条件下上调的SERP1.为神经退行性疾病(如阿尔茨海默病)的研究提供了工具。
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2. **文献名称**: *"SERP1 Antibody Reveals Its Role in Modulating Unfolded Protein Response in Cancer Cells"*
**作者**: Zhang L, et al.
**摘要**: 通过使用SERP1特异性抗体，研究发现SERP1在肿瘤细胞中通过调控IRE1-XBP1信号通路影响未折叠蛋白反应(UPR)。抗体阻断实验表明，SERP1缺失会加剧内质网应激相关的细胞凋亡。
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3. **文献名称**: *"Development and Validation of a Polyclonal SERP1 Antibody for Diagnostic Applications in Cardiovascular Diseases"*
**作者**: Johnson R, et al.
**摘要**: 本文描述了一种高灵敏度的多克隆SERP1抗体的制备，并应用于心肌缺血患者的组织样本分析。结果显示，SERP1在缺血心肌细胞中表达显著升高，提示其可作为心血管疾病的潜在生物标志物。
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4. **文献名称**: *"SERP1 Antibody-Based Screening Identifies Its Interaction with Viral Proteins during Infection"*
**作者**: Lee H, et al.
**摘要**: 利用SERP1抗体进行免疫共沉淀实验，揭示了SERP1与某些病毒蛋白(如流感病毒NS1)的相互作用，表明其在宿主抗病毒反应中可能通过内质网应激通路发挥作用。
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**备注**：若需真实文献，建议通过PubMed或Google Scholar搜索关键词“SERP1 antibody”、“SERP1 function”或结合其别名(如RAMP4)进行查询。
The SERP1 (Stress-associated Endoplasmic Reticulum Protein 1) antibody is a tool used to detect SERP1. a protein encoded by the *SERP1* gene, which belongs to the serine protease inhibitor (serpin) superfamily. Unlike classical serpins, SERP1 lacks protease inhibitory activity and is primarily involved in endoplasmic reticulum (ER)-associated degradation (ERAD), a cellular quality control mechanism that targets misfolded proteins for proteasomal degradation. SERP1. also known as RAMP4. is localized to the ER membrane and interacts with components of the Sec61 translocon, facilitating the recognition and retrotranslocation of aberrant proteins during ER stress.
Research on SERP1 antibodies has been driven by its role in cellular stress responses and diseases linked to protein misfolding, such as neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s) and certain cancers. These antibodies are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study SERP1 expression, localization, and regulation under physiological or pathological conditions. Elevated SERP1 levels have been observed in tumors, suggesting potential roles in cancer progression or therapy resistance. Additionally, SERP1 antibodies aid in exploring ERAD pathway dysregulation, offering insights into therapeutic strategies targeting proteostasis. Their specificity and reliability make them critical for elucidating SERP1’s molecular functions and diagnostic or therapeutic applications.
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