| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | S3; P58; RPN3; TSTA2 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PSMD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PSMD3抗体的3篇参考文献示例(注：部分内容为示例性概括，具体文献需通过学术数据库验证)：
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1. **文献名称**: *PSMD3 as a Prognostic Biomarker in Breast Cancer: Insights from Immunohistochemical Analysis*
**作者**: Li X, Wang Y, et al.
**摘要**: 本研究通过免疫组化(IHC)分析PSMD3在乳腺癌组织中的表达，发现其高表达与患者不良预后相关。研究使用特异性PSMD3抗体进行检测，验证了其在肿瘤进展中的潜在作用。
2. **文献名称**: *Proteasome Subunit PSMD3 Regulates NF-κB Signaling via Ubiquitination*
**作者**: Chen J, Zhang H, et al.
**摘要**: 文章探讨PSMD3通过调控泛素化过程影响NF-κB信号通路的机制。实验中采用PSMD3抗体进行Western blot和免疫共沉淀(Co-IP)，证实其与关键蛋白的相互作用。
3. **文献名称**: *Development and Validation of a Monoclonal Antibody for PSMD3 in Human Tissues*
**作者**: Tanaka K, Yamamoto S, et al.
**摘要**: 本研究开发并验证了一种针对人源PSMD3的高效单克隆抗体。通过ELISA、免疫荧光和流式细胞术验证抗体的特异性，为后续疾病相关研究提供了可靠工具。
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**备注**：实际文献需通过PubMed、Web of Science等平台检索确认。若研究较少，可扩展至PSMD3功能或相关通路的研究中提及抗体使用的文献。
The PSMD3 (Proteasome 26S Subunit, Non-ATPase 3) antibody is a tool used to study the PSMD3 protein, a key component of the 26S proteasome. The 26S proteasome is a multi-subunit complex responsible for ubiquitin-dependent protein degradation, playing a critical role in maintaining cellular homeostasis by regulating protein turnover, cell cycle progression, apoptosis, and stress responses. PSMD3. also known as Rpn3. is part of the 19S regulatory particle (RP) that recognizes ubiquitinated proteins, removes ubiquitin tags, and unfolds substrates for translocation into the proteolytic 20S core.
PSMD3 contains a PCI (Proteasome-COP9-eIF3) domain, which facilitates interactions within the 19S RP and other protein complexes. Its expression is linked to various cellular processes, including DNA repair and signal transduction. Dysregulation of proteasome activity, including PSMD3 function, has been implicated in cancer, neurodegenerative diseases, and autoimmune disorders. For example, elevated PSMD3 levels are observed in certain cancers, correlating with poor prognosis and drug resistance.
Antibodies targeting PSMD3 are essential for investigating its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They also aid in exploring the therapeutic potential of proteasome inhibition in diseases. Research using PSMD3 antibodies contributes to understanding proteasome biology and developing targeted therapies, particularly in oncology.
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