| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SPIN-2; TDRD26; SPIN-2B; dJ323P24.2; SPIN2_duplicate |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SPIN2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SPIN2B抗体的3篇代表性文献(内容基于假设性示例，实际文献需通过学术数据库检索确认)：
1. **文献名称**：*SPIN2B regulates chromatin dynamics during spermatogenesis through histone interactions*
**作者**：Chen L, et al.
**摘要**：本研究利用SPIN2B特异性抗体，通过免疫荧光和ChIP-seq技术，揭示了SPIN2B蛋白通过与组蛋白H3K4me3修饰协同作用，调控精子发生过程中染色质重塑的分子机制。
2. **文献名称**：*A novel monoclonal antibody targeting SPIN2B for detecting early-stage hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：开发了一种高灵敏度SPIN2B单克隆抗体，验证其在肝细胞癌患者血清和组织样本中的高表达特性，提示其作为新型肿瘤标志物的潜在诊断价值。
3. **文献名称**：*SPIN2B deficiency alters neuronal differentiation via Wnt/β-catenin signaling*
**作者**：Kim JH, et al.
**摘要**：通过SPIN2B抗体进行蛋白质互作组分析，发现SPIN2B缺失通过异常激活Wnt通路影响神经干细胞分化，为神经发育障碍提供了新的机制解释。
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**注**：以上为模拟摘要，实际文献请通过PubMed、Web of Science等平台以“SPIN2B antibody”为关键词检索，或结合具体研究方向(如疾病模型、分子机制等)细化检索策略。
The SPIN2B antibody targets the SPIN2B (Spindlin Family Member 2B) protein, a member of the Spindlin family characterized by tandem Tudor-like domains involved in chromatin remodeling and epigenetic regulation. SPIN2B is implicated in diverse cellular processes, including transcriptional regulation, cell cycle progression, and germ cell development. It interacts with histone modifications, such as H3K4me3 and H3K9me3. suggesting roles in reading epigenetic marks and modulating gene expression. Dysregulation of SPIN2B has been linked to cancers, where it may act as an oncogene by promoting proliferation or metastasis.
SPIN2B antibodies are essential tools for detecting protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate SPIN2B’s tissue-specific distribution, particularly in reproductive tissues and tumors. Validated antibodies often undergo specificity checks using knockout controls to ensure reliability.
Research using SPIN2B antibodies spans reproductive biology, oncology, and epigenetics, with studies exploring its potential as a diagnostic marker or therapeutic target. Its conserved structural motifs and interaction partners, such as HP1 proteins, highlight its evolutionary significance in chromatin dynamics. Further investigations aim to clarify its mechanistic roles in disease and development, emphasizing its relevance in both basic and translational research.
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