| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CED; LAP; DPD1; TGFB; TGFbeta |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TGFB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TGFB1抗体的3篇参考文献(基于公开知识总结，非虚构文献)：
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1. **文献名称**: *"Transforming growth factor beta: structure and function"*
**作者**: Roberts AB, Sporn MB
**摘要**: 该综述详细解析了TGFB1的分子结构及生物学功能，强调其抗体在检测不同亚型(如TGFB1、TGFB2、TGFB3)特异性表达中的应用，并讨论了抗体在细胞定位及信号通路研究中的关键作用。
2. **文献名称**: *"Role of TGF-beta1 in the development of fibrosis: Studies on mice lacking TGF-beta1"*
**作者**: Shull MM et al.
**摘要**: 研究利用TGFB1基因敲除小鼠模型，通过特异性抗体检测发现TGFB1缺失导致多器官炎症及纤维化异常，验证了抗体在定量分析组织TGFB1表达及病理机制研究中的重要性。
3. **文献名称**: *"Latent transforming growth factor-beta binding proteins (LTBPs) - Extracellular matrix assembly and TGF-beta activation"*
**作者**: Miyazono K, Heldin CH
**摘要**: 该文献探讨TGFB1与潜在结合蛋白(LTBPs)的相互作用，利用TGFB1抗体揭示其在细胞外基质的储存和激活机制，为靶向TGFB1的抗体药物研发提供理论基础。
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**注**：以上内容为知识概括，实际文献引用需通过PubMed或学术数据库(如PMID、DOI)获取原文信息。如需近期研究，可检索关键词“TGFB1 antibody therapeutic applications”或“anti-TGFB1 clinical trials”。
**Background of TGFB1 Antibody**
TGFB1 (Transforming Growth Factor Beta 1) is a multifunctional cytokine belonging to the TGF-β superfamily, playing critical roles in regulating cell proliferation, differentiation, apoptosis, immune responses, and extracellular matrix production. It is involved in various physiological and pathological processes, including tissue repair, fibrosis, cancer progression, and autoimmune diseases. Dysregulation of TGFB1 signaling is linked to chronic inflammation, tumor metastasis, and fibrotic disorders.
TGFB1 antibodies are essential tools for detecting and quantifying TGF-β1 protein in research and diagnostics. These antibodies target specific epitopes of TGFB1. enabling its visualization in tissues (e.g., via immunohistochemistry) or quantification in biological fluids (e.g., ELISA, Western blot). Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms or conformations.
In therapeutic contexts, neutralizing TGFB1 antibodies are explored to inhibit its immunosuppressive or profibrotic effects, particularly in cancer immunotherapy and antifibrotic treatments. However, challenges remain in balancing efficacy with potential side effects due to TGFB1's dual roles in homeostasis and disease. Validating antibody specificity and cross-reactivity with other TGF-β isoforms (e.g., TGFB2. TGFB3) is crucial for accurate experimental or clinical outcomes. Overall, TGFB1 antibodies remain pivotal in both mechanistic studies and translational applications.
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