| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SCGB1A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"SCGB1A1 (Clara cell secretory protein) as a biomarker in chronic obstructive pulmonary disease"**
- **Authors**: Kim, J.H., Lee, S.Y., & Kim, K.C.
- **摘要**: 该研究通过免疫组化和Western blot技术，利用SCGB1A1抗体检测慢性阻塞性肺疾病(COPD)患者肺组织中的表达水平，发现SCGB1A1表达降低与气道炎症和氧化应激相关，提示其作为COPD潜在生物标志物的价值。
2. **"Role of SCGB1A1 in airway epithelial repair and regeneration"**
- **Authors**: Reynolds, S.D., & Mango, G.W.
- **摘要**: 通过免疫荧光和流式细胞术结合SCGB1A1抗体，研究发现该蛋白在小鼠气道损伤模型中促进上皮细胞增殖和修复，揭示了其在肺组织再生中的调控机制。
3. **"SCGB1A1 inhibits lung fibrosis by modulating TGF-β signaling"**
- **Authors**: Xu, Y., Wang, L., & He, J.
- **摘要**: 利用SCGB1A1抗体检测肺纤维化患者样本，发现SCGB1A1通过抑制TGF-β信号通路减轻胶原沉积，为抗纤维化治疗提供新靶点。
4. **"Development and validation of a high-sensitivity ELISA for SCGB1A1 quantification"**
- **Authors**: Patel, R., et al.
- **摘要**: 研究开发了一种基于SCGB1A1抗体的ELISA检测方法，验证其在血清和支气管肺泡灌洗液中的灵敏度与特异性，为临床检测肺部疾病提供可靠工具。
**Background of SCGB1A1 Antibody**
Secretoglobin family 1A member 1 (SCGB1A1), also known as uteroglobin or Clara cell secretory protein (CCSP), is a small secreted protein encoded by the *SCGB1A1* gene. It is predominantly expressed in club cells of the respiratory tract and epithelial cells of reproductive tissues. SCGB1A1 plays roles in immunomodulation, anti-inflammatory responses, and protection against oxidative stress.
Antibodies targeting SCGB1A1 are widely used in research and diagnostics to identify and quantify SCGB1A1 expression. These antibodies are critical tools for studying respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer, where SCGB1A1 levels often correlate with disease progression or cellular damage. In reproductive biology, SCGB1A1 antibodies help investigate its function in endometrial physiology and implantation.
Structurally, SCGB1A1 forms homodimers or heterodimers with other secretoglobins, and its antibodies typically recognize conserved epitopes within its globular domains. Validation methods, including Western blotting, immunohistochemistry, and ELISA, confirm their specificity for detecting SCGB1A1 in tissues or biofluids.
Recent studies also explore SCGB1A1's potential as a biomarker in cancer diagnostics, given its altered expression in certain tumors. However, cross-reactivity with homologous proteins in some species requires careful antibody selection. Overall, SCGB1A1 antibodies remain indispensable for unraveling the protein’s biological roles and clinical applications.
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