| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CIDEB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CIDEB抗体相关的研究文献概览(注：文献信息为模拟创作，仅供格式参考)：
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1. **文献名称**：CIDEB mediates hepatic lipid droplet homeostasis via antibody-detected protein interactions
**作者**：Li Y, et al.
**摘要**：研究利用CIDEB特异性抗体验证了其在肝细胞脂滴融合中的关键作用，通过免疫共沉淀技术揭示了CIDEB与脂代谢相关蛋白的相互作用网络，证实其缺失导致脂肪变性加剧。
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2. **文献名称**：Anti-CIDEB autoantibodies as a novel biomarker in non-alcoholic steatohepatitis
**作者**：Zhang X, et al.
**摘要**：首次报道了抗CIDEB自身抗体在非酒精性脂肪性肝炎(NASH)患者血清中的异常表达，通过ELISA和Western blot验证其与疾病严重程度的相关性，提示其潜在诊断价值。
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3. **文献名称**：CIDEB knockout validation using CRISPR and antibody-based phenotypic analysis
**作者**：Wang H, et al.
**摘要**：研究通过CRISPR构建CIDEB敲除细胞模型，结合免疫荧光和流式细胞术(使用CIDEB单克隆抗体)证实基因缺失导致细胞凋亡通路异常激活，为肝癌治疗提供新靶点。
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*注：实际文献需通过PubMed/Google Scholar等平台以关键词"CIDEB antibody"+"specific function"检索，建议优先选择近五年内高被引论文。*
The CIDEB (Cell Death-Inducing DFFA-like Effector B) antibody is a research tool targeting the CIDEB protein, a member of the CIDE (Cell Death-Inducing DFF45-like Effector) family. CIDEB plays a dual role in lipid metabolism and apoptosis regulation. It is primarily expressed in metabolic tissues like the liver and adipose tissue, where it regulates lipid droplet fusion and lipid storage. CIDEB interacts with other lipid droplet-associated proteins (e.g., PLIN1) to influence lipid homeostasis, with implications in metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and obesity. Its apoptotic function involves binding to DNA fragmentation factors in certain stress conditions.
CIDEB antibodies are critical for studying these biological processes. They enable protein detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping researchers map CIDEB's tissue distribution, subcellular localization, and expression changes under physiological/pathological conditions. Some studies also explore CIDEB's potential as a therapeutic target for metabolic diseases. As commercial CIDEB antibodies vary in specificity (monoclonal vs. polyclonal) and host species (rabbit, mouse), validation using knockout controls is essential. Recent interest in CIDEB antibodies has grown alongside advances in lipid metabolism research and the global rise of metabolic syndromes.
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