Rabbit Polyclonal VPS18 Antibody

The VPS18 antibody is a research tool designed to detect and study VPS18 (Vacuolar Protein Sorting 18), a critical component of cellular trafficking machinery. VPS18 is a member of the HOPS (Homotypic Fusion and Protein Sorting) complex, which facilitates lysosome-endosome fusion, autophagosome maturation, and vesicular transport in eukaryotic cells. It plays a pivotal role in endolysosomal trafficking, membrane fusion, and organelle biogenesis by coordinating interactions between Rab GTPases, SNARE proteins, and other trafficking regulators. Mutations in VPS18 are linked to lysosomal storage disorders and immune dysregulation, highlighting its importance in cellular homeostasis. Researchers use VPS18 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in models of neurodegeneration, cancer, and genetic diseases. These antibodies help elucidate mechanisms underlying defects in vesicular transport, autophagy, and organelle dysfunction. Commercial VPS18 antibodies are typically raised against specific epitopes, with validation in human, mouse, or rat samples. Its study contributes to understanding pathologies like Hermansky-Pudlak syndrome and potential therapeutic targets for lysosome-related disorders.