Rabbit Polyclonal PCDHB16 Antibody

The PCDHB16 antibody is a specialized tool used to detect and study the protocadherin beta-16 protein, a member of the protocadherin β (PCDH-β) subfamily within the cadherin superfamily. Protocadherins are transmembrane proteins involved in cell-cell adhesion, neuronal development, and synaptic connectivity. The PCDH-β cluster, located on chromosome 5q31 in humans, comprises 16 genes (PCDHB1-PCDHB16) that exhibit cell-type-specific expression patterns in the central nervous system. PCDHB16. in particular, is thought to contribute to neural circuit formation, axon guidance, and the establishment of synaptic specificity through homophilic or heterophilic interactions. Its expression is tightly regulated during brain development, suggesting roles in neuroplasticity and maintenance of neural networks. Antibodies targeting PCDHB16 enable researchers to investigate its spatial and temporal distribution in tissues, assess protein-protein interactions, or explore its involvement in neurological disorders, such as autism spectrum disorders, schizophrenia, or neurodegenerative diseases. These antibodies are commonly validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also implicate PCDHB16 dysregulation in certain cancers, expanding its potential relevance to oncology research. As a relatively less characterized protocadherin, PCDHB16 antibodies remain critical for elucidating its functional diversity beyond classical cadherin roles in adhesion.