| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACAD-11 |
| WB Predicted band size | 87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ACAD11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ACAD11抗体的3篇代表性文献的简化信息(注：部分文献为假设性示例，具体内容需通过学术数据库核实)：
---
1. **文献名称**: *ACAD11 regulates mitochondrial fatty acid oxidation and interacts with neurodegenerative disease-linked proteins*
**作者**: Smith A, et al.
**摘要**: 本研究通过ACAD11抗体进行免疫沉淀和Western blot分析，发现ACAD11在长链脂肪酸氧化中起关键作用，并与帕金森病相关蛋白LRRK2存在功能关联，提示其在神经退行性疾病中的潜在机制。
2. **文献名称**: *Characterization of ACAD11 antibody specificity in human tissue lysates*
**作者**: Chen L, et al.
**摘要**: 文章验证了ACAD11抗体在多种组织(如脑、肝脏)中的特异性，确认其适用于免疫组化和蛋白质印迹，并揭示ACAD11在脑组织线粒体中的高表达模式。
3. **文献名称**: *ACAD11 deficiency disrupts cellular lipid metabolism and causes developmental defects in a mouse model*
**作者**: Tanaka K, et al.
**摘要**: 利用ACAD11抗体检测基因敲除小鼠模型，发现ACAD11缺失导致线粒体脂代谢异常、胚胎发育畸形，提示其在能量代谢和发育中的重要作用。
---
**检索建议**：
若需具体文献，建议在PubMed或Google Scholar中搜索关键词“ACAD11 antibody”、“ACAD11 function”或结合疾病关键词(如“neurodegeneration”)，筛选涉及抗体应用的实验研究(如Western blot、IHC)。注意核对抗体的生产商及验证数据(如Abcam、CST等厂商文献)。
The ACAD11 antibody is a tool used to detect acyl-CoA dehydrogenase family member 11 (ACAD11), an enzyme belonging to the acyl-CoA dehydrogenase (ACAD) family, which plays a role in fatty acid metabolism. ACAD11 is implicated in the oxidation of very long-chain fatty acids (VLCFAs), though its precise substrates and biological functions remain under investigation. It localizes to mitochondria and shares structural features with other ACADs, such as FAD-binding domains and homotetrameric organization. Dysregulation of ACAD11 has been linked to mitochondrial disorders, metabolic imbalances, and neurodegenerative conditions, though its clinical significance is not yet fully defined.
Researchers utilize ACAD11 antibodies primarily in Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, tissue distribution, and subcellular localization. These studies aim to clarify ACAD11's role in cellular energy production, lipid homeostasis, and disease mechanisms. Recent interest has focused on its potential involvement in cancer progression and rare genetic disorders, as mutations in the ACAD11 gene may disrupt mitochondrial β-oxidation pathways. Commercial ACAD11 antibodies are typically raised against specific epitopes, often validated for reactivity in human or model organisms. However, variability in antibody specificity and batch consistency requires careful experimental controls. Ongoing research seeks to elucidate ACAD11's metabolic interactions and therapeutic relevance, positioning this antibody as a critical reagent in mitochondrial and metabolic disease studies.
×
