| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | DSAEC |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ACAA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条与ACAA2抗体相关的参考文献示例(注：内容为模拟生成，仅供格式参考)：
1. **"Characterization of ACAA2-specific antibodies for mitochondrial protein analysis"**
- 作者：Li, X. et al.
- 摘要：研究报道了针对ACAA2蛋白的多克隆抗体的开发与验证，通过免疫印迹和免疫荧光证实其在检测线粒体中ACAA2表达的适用性，并探讨了ACAA2在脂肪酸氧化中的作用。
2. **"ACAA2 expression and antibody-based detection in hepatocellular carcinoma"**
- 作者：Wang, Y. et al.
- 摘要：利用ACAA2特异性抗体分析肝癌组织中ACAA2的蛋白水平，发现其表达下调与肿瘤代谢异常相关，提示其可能作为潜在生物标志物。
3. **"A novel monoclonal antibody targeting ACAA2 for functional studies in vitro"**
- 作者：Garcia-Ruiz, C. et al.
- 摘要：开发了一种高特异性抗ACAA2单克隆抗体，验证其在流式细胞术和免疫沉淀中的应用，揭示了ACAA2与过氧化物酶体代谢途径的关联。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“ACAA2 antibody”或“Acetyl-CoA acyltransferase 2”，并筛选近年发表的实验研究类文章。
ACAA2 (Acetyl-CoA Acyltransferase 2) is a mitochondrial enzyme involved in lipid metabolism, specifically the β-oxidation of fatty acids. It catalyzes the final step of this pathway, cleaving medium-chain fatty acyl-CoA into acetyl-CoA and a shortened acyl-CoA molecule, which is critical for energy production. ACAA2 is encoded by the ACAA2 gene located on human chromosome 18q21.1 and shares structural homology with other thiolases in its family, featuring conserved catalytic residues.
Research on ACAA2 antibodies has gained attention due to their utility in studying metabolic disorders, neurodegenerative diseases, and cancer. Dysregulation of ACAA2 expression has been linked to impaired fatty acid oxidation, contributing to conditions like mitochondrial dysfunction and insulin resistance. In cancer, altered ACAA2 levels are associated with tumor progression and metabolic reprogramming.
Antibodies targeting ACAA2 are essential tools for detecting protein expression via Western blotting, immunohistochemistry, or immunofluorescence. They help elucidate its tissue distribution (e.g., high expression in liver, heart, and kidney) and subcellular localization. Commercial ACAA2 antibodies are typically raised against specific epitopes, such as recombinant protein fragments, and validated for specificity. Recent studies also explore ACAA2's role in cellular stress responses, making these antibodies valuable for both diagnostic and mechanistic research in metabolic and oncogenic pathways.
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