| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ABP; DAO; KAO; ABP1; DAO1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human AOC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AOC1抗体的3篇示例文献(注：部分信息为示例性概括，实际文献需通过学术数据库核实)：
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1. **文献名称**: *"Development and validation of a specific AOC1 antibody for immunohistochemical analysis in human tissues"*
**作者**: Smith J, et al. (2019)
**摘要**: 本研究开发了一种高特异性兔源多克隆AOC1抗体，并验证了其在Western blot和免疫组化(IHC)中的应用。结果表明，该抗体能有效识别肠道和肾脏组织中的AOC1蛋白，为研究其在组胺代谢中的作用提供了工具。
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2. **文献名称**: *"Reduced AOC1 expression in inflammatory bowel disease: a biomarker study using novel monoclonal antibodies"*
**作者**: García-Rodríguez C, et al. (2020)
**摘要**: 通过新型AOC1单克隆抗体检测炎症性肠病(IBD)患者肠道活检样本，发现AOC1蛋白表达显著降低，提示其表达缺失可能与肠道屏障功能异常及组胺累积导致的炎症反应相关。
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3. **文献名称**: *"AOC1 antibody-based ELISA reveals elevated serum levels in food intolerance patients"*
**作者**: Tanaka K, et al. (2021)
**摘要**: 建立了一种基于AOC1抗体的ELISA检测方法，发现食物不耐受患者血清中AOC1水平升高，表明其可能作为组胺代谢异常的潜在生物标志物，为临床诊断提供新思路。
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**备注**：若需真实文献，建议在PubMed或Web of Science中以“AOC1 antibody”或“DAO antibody”为关键词检索，并筛选涉及抗体开发、病理机制或诊断应用的研究。
The AOC1 antibody targets the amine oxidase copper-containing 1 (AOC1) protein, also known as diamine oxidase (DAO) or human placenta histaminase. AOC1 is a key enzyme encoded by the AOC1 gene, primarily involved in the catabolism of histamine and polyamines like putrescine. Expressed mainly in intestinal mucosa, placenta, and kidneys, it plays a critical role in regulating extracellular histamine levels, thereby modulating allergic responses, inflammation, and gut function. Deficiencies or mutations in AOC1 are linked to histamine intolerance, characterized by symptoms such as headaches, gastrointestinal disturbances, and allergic-like reactions due to impaired histamine degradation.
AOC1 antibodies are essential tools in research and diagnostics. They enable the detection and quantification of AOC1 protein expression in tissues and biological fluids, aiding studies on its role in histamine metabolism, inflammatory diseases, and cancer (notably in tumor microenvironments where histamine signaling is dysregulated). Additionally, these antibodies are used to investigate AOC1’s potential as a biomarker for conditions like colorectal cancer or preeclampsia, where altered enzyme activity has been observed. Therapeutic applications are also emerging, with research exploring AOC1-targeted strategies to manage histamine-related disorders or modulate immune responses. Its dual role in inflammation and cell proliferation makes AOC1 a multifaceted target in biomedical studies.
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