| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ABI2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ABI2抗体的参考文献示例(注：部分文献信息为模拟虚构，实际引用时请核实原文)：
1. **文献名称**: "ABI2 regulates neuronal migration and dendritic arborization through WAVE complex interaction"
**作者**: Smith J, et al. (2020)
**摘要**: 本研究利用特异性ABI2抗体揭示了ABI2蛋白在神经元发育中的作用，证明其通过调控WAVE复合体活性影响细胞骨架重组，从而调节神经元迁移和树突形态发生。
2. **文献名称**: "Development and validation of a monoclonal ABI2 antibody for immunohistochemical analysis in breast cancer"
**作者**: Li X, et al. (2018)
**摘要**: 文章报道了一种高特异性单克隆ABI2抗体的开发，验证了其在乳腺癌组织中的免疫组化应用，发现ABI2低表达与肿瘤转移和患者预后不良显著相关。
3. **文献名称**: "ABI2 deficiency disrupts podocyte cytoskeleton in diabetic nephropathy: Insights from knockout mouse models"
**作者**: Wang Y, et al. (2021)
**摘要**: 通过ABI2抗体检测基因敲除小鼠肾组织，发现ABI2缺失导致足细胞骨架蛋白异常表达，加剧糖尿病肾病进展，提示ABI2在肾脏疾病中的保护性作用。
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**提示**：实际研究中建议通过PubMed或Web of Science检索关键词"ABI2 antibody"或"ABI2 protein"，筛选应用该抗体的功能研究或抗体开发类文献。部分商业化抗体厂商(如CST、Abcam)的产品说明书也会提供关键参考文献。
The ABI2 (Abelson Interactor 2) antibody is a tool used to study the ABI2 protein, a member of the ABI family involved in regulating intracellular signaling pathways. ABI2 interacts with Abelson tyrosine kinase (ABL) and other proteins, playing a role in cytoskeletal reorganization, cell migration, and membrane trafficking. It is a key component of the WAVE regulatory complex (WRC), which modulates actin polymerization by activating the Arp2/3 complex. Dysregulation of ABI2 has been implicated in neurological disorders, such as Alzheimer’s disease, and cancer progression due to its influence on cell motility and invasion.
Research using ABI2 antibodies focuses on elucidating its molecular interactions, particularly in neuronal development, synaptic plasticity, and tumor metastasis. These antibodies enable detection of ABI2 expression levels, subcellular localization (e.g., cytoplasm or membrane), and post-translational modifications via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies also explore ABI2's tumor-suppressive or oncogenic roles in various cancers, depending on cellular context. Its involvement in pathways like EGFR signaling further highlights therapeutic potential. ABI2 antibodies thus serve as critical reagents for understanding cellular dynamics and disease mechanisms linked to cytoskeletal regulation.
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