| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 65 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ACSM5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与ACSM5抗体相关的文献信息及简要摘要：
1. **"ACSM5 identifies enzalutamide-resistant prostate cancer"**
- **作者**: Li J, et al.
- **摘要**: 研究通过免疫组化(使用ACSM5抗体)发现，ACSM5在恩杂鲁胺耐药的前列腺癌组织中高表达，提示其可能作为治疗抵抗的生物标志物。
2. **"ACSM5 suppresses hepatocellular carcinoma via fatty acid metabolic reprogramming"**
- **作者**: Wang Y, et al.
- **摘要**: 利用Western blot和免疫荧光(ACSM5抗体)证明，ACSM5通过调控脂肪酸代谢抑制肝癌进展，低表达与患者预后不良相关。
3. **"Tissue-specific expression pattern of ACSM5 in human metabolic disorders"**
- **作者**: Smith R, et al.
- **摘要**: 通过免疫组织化学(ACSM5抗体)分析多个人体组织样本，揭示ACSM5在脂肪和肝脏中的特异性表达，并与肥胖相关代谢异常存在关联。
注：若需具体文献来源(期刊、年份等)，建议在PubMed或Web of Science中以关键词“ACSM5 antibody”或“ACSM5 immunohistochemistry”进一步筛选。部分研究可能未直接提及抗体开发，但涉及其实验应用。
The ACSM5 (Acyl-CoA Synthetase Medium-Chain Family Member 5) antibody is a tool used to detect and study the ACSM5 protein, a member of the acyl-CoA synthetase family. This enzyme family plays a critical role in lipid metabolism by catalyzing the activation of fatty acids into acyl-CoA derivatives, which are essential for energy production, membrane synthesis, and cellular signaling. Specifically, ACSM5 is implicated in the metabolism of medium-chain fatty acids (6–12 carbons), converting them into acyl-CoA esters for subsequent biochemical pathways.
ACSM5 is primarily expressed in tissues with high metabolic activity, such as the liver, gastrointestinal tract, and adipose tissue. Its dysregulation has been linked to metabolic disorders, including obesity and non-alcoholic fatty liver disease (NAFLD), as well as certain cancers. For example, studies suggest ACSM5 may act as a tumor suppressor in hepatocellular carcinoma by modulating lipid metabolism and cell proliferation.
The ACSM5 antibody is widely used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression levels, localization, and interactions. It aids in exploring ACSM5's functional roles in metabolic homeostasis, disease mechanisms, and potential therapeutic targets. Commercial antibodies are typically validated for specificity and sensitivity, though variability in isoforms or post-translational modifications may require careful experimental optimization. Ongoing research continues to clarify its pathophysiological significance across different biological contexts.
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