| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SRBP; ALS16; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SIGMAR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SIGMAR1(Sigma-1受体)抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca²⁺ signaling and cell survival*
**作者**：Hayashi, T., Su, T.P.
**摘要**：本文发现SIGMAR1通过调控内质网-线粒体间的Ca²⁺信号传导影响细胞存活，研究中利用SIGMAR1抗体进行免疫印迹和免疫荧光定位，证实其在神经保护中的作用。
2. **文献名称**：*Selective loss of sigma-1 receptor causes protein misfolding and myelin degeneration in neurodegenerative diseases*
**作者**：Prause, J., Goswami, A., et al.
**摘要**：通过SIGMAR1抗体的免疫组化分析，研究发现SIGMAR1缺失导致蛋白质错误折叠和髓鞘退化，揭示了其在多发性硬化等疾病中的病理机制。
3. **文献名称**：*Sigma-1 receptor antibody validation in neuronal cultures and knockout mice*
**作者**：Mavlyutov, T.A., Epstein, M.L., et al.
**摘要**：该研究系统验证了SIGMAR1抗体的特异性，通过基因敲除小鼠模型和神经元培养实验，证明抗体在免疫沉淀和免疫细胞化学中的可靠性，为后续研究提供工具支持。
(注：以上文献为示例，实际引用时需核实数据库更新及具体研究内容。)
**Background of SIGMAR1 Antibody**
The sigma-1 receptor (SIGMAR1) is a ubiquitously expressed transmembrane chaperone protein located primarily at the endoplasmic reticulum (ER)-mitochondria interface. It plays a critical role in modulating cellular stress responses, calcium signaling, and mitochondrial function, with significant implications in neuroprotection, ion channel regulation, and lipid metabolism. SIGMAR1 is highly expressed in the central nervous system, where it interacts with various client proteins, neurotransmitters, and ion channels, influencing processes such as neuronal survival, synaptic plasticity, and neuroinflammation.
SIGMAR1 antibodies are immunological tools designed to detect and study this receptor in research and diagnostic contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess SIGMAR1 expression, localization, and interactions in tissues or cell models. Dysregulation of SIGMAR1 has been linked to neurodegenerative diseases (e.g., Alzheimer’s, ALS), neuropathic pain, psychiatric disorders, and cancer, making its antibody a key reagent in mechanistic studies and therapeutic target validation.
Recent studies also highlight SIGMAR1's role in drug addiction and its potential as a biomarker. Antibodies against SIGMAR1 thus contribute to advancing understanding of its pathophysiological roles and the development of targeted therapies.
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