| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GUCY1A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GUCY1A1抗体的3篇示例文献(内容基于领域内常见研究方向，具体文献需通过数据库核实)：
1. **文献名称**：*GUCY1A1 Expression in Vascular Smooth Muscle Cells Regulates Nitric Oxide Signaling*
**作者**：Smith A, et al.
**摘要**：研究通过Western blot和免疫荧光技术，利用GUCY1A1抗体发现其在动脉粥样硬化模型中表达下调，提示其通过cGMP通路影响血管张力与疾病进展。
2. **文献名称**：*Role of GUCY1A1 in Tumor Angiogenesis: Immunohistochemical Analysis*
**作者**：Chen L, et al.
**摘要**：使用GUCY1A1抗体对癌症组织进行免疫组化分析，发现其高表达与肿瘤血管生成相关，可能成为抗血管治疗的潜在靶点。
3. **文献名称**：*GUCY1A1 Antibody Validation for Neurological Disease Models*
**作者**：Wang X, et al.
**摘要**：本研究验证了GUCY1A1抗体的特异性，证明其在中风小鼠模型中检测到GUCY1A1蛋白水平变化，提示该蛋白在神经保护中的作用。
**备注**：以上为模拟示例，实际文献请通过PubMed、Google Scholar等平台以“GUCY1A1 antibody”或“GUCY1A1 function”为关键词检索获取。
**Background of GUCY1A1 Antibody**
GUCY1A1 (Guanylate Cyclase 1 Soluble Subunit Alpha 1) is a critical component of the nitric oxide (NO) signaling pathway. It forms a heterodimer with GUCY1B1 to create soluble guanylate cyclase (sGC), an enzyme that catalyzes the conversion of GTP to cyclic GMP (cGMP) upon NO binding. This cGMP-dependent signaling regulates vascular tone, platelet aggregation, and smooth muscle relaxation, playing roles in cardiovascular homeostasis, neuronal signaling, and other physiological processes. Dysregulation of GUCY1A1/sGC activity is linked to hypertension, atherosclerosis, pulmonary hypertension, and cancer progression.
GUCY1A1 antibodies are essential tools for studying the expression, localization, and function of the GUCY1A1 subunit in research. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein levels in tissues or cells. Commercially available antibodies are typically raised against specific epitopes of human GUCY1A1. with cross-reactivity validated in common model organisms. Researchers also utilize these antibodies to investigate pathological mechanisms, such as altered NO-sGC-cGMP signaling in cardiovascular diseases, or to evaluate therapeutic targets like sGC stimulators/activators. Specificity validation (e.g., via knockout controls) is crucial due to structural similarities among guanylate cyclase family members.
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