Rabbit Polyclonal RICTOR Antibody

The RICTOR (Rapamycin-insensitive companion of mTOR) antibody is a crucial tool for studying the mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cell survival, metabolism, and proliferation. RICTOR is a defining subunit of mTORC2. distinguishing it from mTORC1. another mTOR-containing complex. mTORC2 phosphorylates downstream kinases like AKT (at Ser473), SGK1. and PKCα, influencing processes such as glucose homeostasis, cytoskeletal organization, and apoptosis. Dysregulation of RICTOR/mTORC2 is implicated in cancer, metabolic disorders, and aging, making it a therapeutic target. Antibodies targeting RICTOR enable researchers to investigate its expression, complex assembly, and signaling roles. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess protein levels, localization, and interactions. Specificity and validation are critical, as cross-reactivity with homologous proteins (e.g., mTORC1 components) can confound results. Commercial RICTOR antibodies are typically raised against epitopes within its conserved regions (e.g., N-terminal or central domains) and validated using knockout cell lines. Recent studies also explore RICTOR's role in tumor progression and drug resistance, underscoring the antibody's importance in both basic research and clinical applications.