| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | URK1 |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UCK1抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**: *"UCK1 expression is associated with poor prognosis in colorectal cancer patients"*
**作者**: Zhang Y, et al. (2020)
**摘要**: 本研究通过免疫组化分析结直肠癌组织中UCK1蛋白表达，发现其高表达与患者总生存期缩短显著相关。研究利用特异性UCK1抗体证实其在肿瘤增殖中的作用，提示UCK1可能作为预后生物标志物。
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2. **文献名称**: *"Role of UCK1 in cell cycle regulation through nucleotide metabolism"*
**作者**: Lee S, et al. (2018)
**摘要**: 作者使用UCK1抗体进行Western blot和免疫荧光实验，发现UCK1通过调控尿苷磷酸化影响细胞周期进程。实验显示，UCK1敲低导致G1/S期阻滞，提示其在代谢与增殖中的关键作用。
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3. **文献名称**: *"Development of a monoclonal antibody targeting UCK1 for functional studies"*
**作者**: Smith J, et al. (2019)
**摘要**: 该研究报道了一种新型抗UCK1单克隆抗体的开发与验证，通过ELISA、免疫沉淀等实验确认其高特异性。该抗体成功应用于检测多种癌症细胞系中UCK1的表达差异。
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**备注**：上述文献信息为示例性质，实际引用时需核实具体文献来源及内容准确性。建议通过PubMed或Web of Science以“UCK1 antibody”、“UCK1 function”等关键词检索最新研究。
Uridine-cytidine kinase 1 (UCK1) is a metabolic enzyme involved in the pyrimidine salvage pathway, which plays a critical role in phosphorylating uridine and cytidine to form UMP and CMP—key precursors for RNA synthesis and cellular proliferation. UCK1 is ubiquitously expressed but shows elevated activity in rapidly dividing cells, such as cancer cells, due to its role in maintaining nucleotide pools. Research has linked UCK1 dysregulation to various diseases, including cancers (e.g., hepatocellular carcinoma, colorectal cancer) and viral infections, where its activity supports viral RNA replication. UCK1 antibodies are essential tools for studying its expression, localization, and function in these contexts.
UCK1-specific antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines. They help identify UCK1 overexpression in tumors, which may correlate with poor prognosis or drug resistance. Additionally, these antibodies aid in exploring UCK1's interaction with antiviral agents or chemotherapeutics that target nucleotide metabolism. Recent studies also investigate UCK1's potential as a therapeutic target, particularly in cancers reliant on the salvage pathway.
Developed in various host species (e.g., rabbit, mouse), UCK1 antibodies are validated for specificity and sensitivity, enabling precise detection in both research and diagnostic settings. Their applications extend to drug development, such as screening UCK1 inhibitors to disrupt nucleotide synthesis in pathological conditions.
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