| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | LZK; MLK; MEKK13 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MAP3K13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAP3K13抗体的3篇参考文献示例(注：内容为虚构，仅作格式参考)：
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1. **文献名称**: *MAP3K13 Expression in Glioblastoma Progression*
**作者**: Smith A, et al. (2020)
**摘要**: 本研究通过Western blot和免疫组化(使用MAP3K13特异性抗体)发现，MAP3K13在胶质母细胞瘤组织中高表达，且与患者生存期缩短显著相关。抗体验证显示其可特异性识别肿瘤细胞中的磷酸化MAP3K13蛋白。
2. **文献名称**: *Role of MAP3K13 in Neuroinflammatory Pathways*
**作者**: Chen B, et al. (2018)
**摘要**: 利用MAP3K13抗体进行免疫荧光染色，作者发现MAP3K13在小鼠脑部小胶质细胞中激活JNK通路，促进神经炎症反应。抗体特异性通过siRNA敲低实验验证。
3. **文献名称**: *MAP3K13 Promotes Hepatocellular Carcinoma Invasion*
**作者**: Zhang Y, et al. (2019)
**摘要**: 通过免疫沉淀(使用抗MAP3K13抗体)和功能实验，研究揭示MAP3K13通过调控ERK信号通路增强肝癌细胞迁移。抗体在组织微阵列分析中用于评估临床样本中的蛋白表达水平。
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(注：实际文献需通过PubMed、Google Scholar等平台检索确认。)
MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13), also known as LZK or MLK3. is a serine/threonine kinase belonging to the MAP3K family, which plays a critical role in regulating the MAPK signaling cascade. This pathway is involved in diverse cellular processes, including proliferation, differentiation, apoptosis, and stress responses. MAP3K13 specifically activates downstream kinases like MKK7. which in turn phosphorylate JNK (c-Jun N-terminal kinase) and p38 MAPK, influencing pathways linked to inflammation, neuronal survival, and cancer progression.
Antibodies targeting MAP3K13 are essential tools for studying its expression, activation status, and interactions in cellular contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate its role in diseases. For example, MAP3K13 has been implicated in neurodegenerative disorders (e.g., Alzheimer’s disease) due to its involvement in neuronal stress responses, and in cancers (e.g., glioblastoma, hepatocellular carcinoma) where its dysregulation may promote tumor growth or resistance to therapy. Additionally, MAP3K13 is linked to metabolic and inflammatory pathways, making it a potential therapeutic target.
These antibodies often recognize specific epitopes or phosphorylation sites (e.g., Thr280/Ser282) to assess kinase activity. Validation in knock-out models or siRNA-treated samples ensures specificity. Researchers rely on MAP3K13 antibodies to explore its dual roles in cell survival/death and to develop targeted therapies modulating MAPK signaling.
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