| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HKD; HKI; HXK1; HMSNR; HK1-ta; HK1-tb; HK1-tc |
| WB Predicted band size | 102 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3-4条关于HK1(Hexokinase 1)抗体的参考文献示例(文献信息为模拟概括，实际文献需通过学术数据库验证)：
1. **"Autoantibodies against Hexokinase 1 in Patients with Cerebellar Ataxia"**
- **作者**: Tanaka K, et al.
- **摘要**: 研究报道了在特发性小脑共济失调患者血清中检测到HK1自身抗体，提示HK1可能作为自身免疫性神经系统疾病的潜在生物标志物，并探讨了其与神经细胞损伤的关联性。
2. **"Hexokinase 1 as a Metabolic Target in Cancer Therapy: Antibody-Based Detection and Functional Analysis"**
- **作者**: Chen L, et al.
- **摘要**: 通过抗HK1抗体进行免疫组化和Western blot分析，揭示了HK1在多种实体瘤中的高表达，并证明其与肿瘤细胞糖酵解活性和化疗耐药性相关，为靶向HK1的癌症治疗提供依据。
3. **"Development of a Novel HK1-Specific Monoclonal Antibody for Biomarker Discovery in Alzheimer’s Disease"**
- **作者**: Smith J, et al.
- **摘要**: 研究团队开发了一种高特异性HK1单克隆抗体，用于检测阿尔茨海默病患者脑脊液和脑组织中的HK1水平变化，发现HK1异常聚集可能与线粒体功能障碍和神经元退行性变有关。
4. **"HK1 Autoantibodies in Paraneoplastic Neurological Syndromes: A Retrospective Cohort Study"**
- **作者**: Lee S, et al.
- **摘要**: 回顾性分析显示，HK1自身抗体在副肿瘤性神经综合征(PNS)患者中有较高检出率，尤其与肺癌和乳腺癌相关，提示其可能作为PNS的辅助诊断指标。
**注意**：以上文献名称及内容为示例性质，实际引用需查询PubMed、Web of Science等数据库获取真实文献。
HK1 antibody targets hexokinase 1 (HK1), a key enzyme in glycolysis that catalyzes the phosphorylation of glucose to glucose-6-phosphate. HK1 is ubiquitously expressed, with high levels in tissues dependent on aerobic glycolysis, such as the brain, muscles, and red blood cells. It localizes to the outer mitochondrial membrane, linking glycolysis to oxidative phosphorylation—a critical metabolic coordination point. Dysregulation of HK1 is implicated in diseases like cancer, where altered glycolysis supports tumor growth, and neurodegenerative disorders, where mitochondrial dysfunction occurs.
HK1 antibodies are widely used in research to study metabolic adaptations in pathologies. In cancer biology, they help assess HK1 expression patterns in tumors, correlating with aggressiveness or therapeutic resistance. In neuroscience, these antibodies aid in exploring HK1’s role in neuronal survival and its potential involvement in Alzheimer’s or Parkinson’s disease. Additionally, HK1 autoantibodies have been identified in autoimmune conditions, such as paraneoplastic neurological syndromes, serving as diagnostic biomarkers.
Commercially available HK1 antibodies are typically monoclonal or polyclonal, validated for techniques like Western blot, immunohistochemistry, and immunofluorescence. Specificity is crucial due to homology among hexokinase isoforms (HK1. HK2. HK3). Recent studies also investigate HK1 inhibitors for therapeutic targeting in metabolic diseases. Overall, HK1 antibodies remain vital tools for dissecting cellular metabolism and disease mechanisms.
×
