| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | M6A; GPM6 |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GPM6A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPM6A抗体的3篇虚构参考文献示例(基于类似研究主题的合理推测，非真实文献)：
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1. **文献名称**: "Characterization of a novel polyclonal antibody for GPM6A in neuronal membrane localization studies"
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对GPM6A C端表位的兔多克隆抗体，验证了其在Western blot和免疫组化中的特异性。实验表明，GPM6A主要定位于海马神经元膜上，并参与神经突触的可塑性调节。
2. **文献名称**: "GPM6A expression is reduced in schizophrenia: Evidence from postmortem brain analysis using a validated antibody"
**作者**: Lee H, et al.
**摘要**: 通过使用特异性抗体验证，作者发现精神分裂症患者前额叶皮质中GPM6A蛋白表达显著降低。该抗体经敲除小鼠模型验证无交叉反应，支持GPM6A在精神疾病中的潜在病理作用。
3. **文献名称**: "GPM6A interacts with the mTOR signaling pathway: Insights from co-immunoprecipitation assays"
**作者**: Garcia R, et al.
**摘要**: 利用GPM6A特异性抗体进行免疫共沉淀实验，揭示了GPM6A与mTOR通路蛋白的相互作用，提示其可能通过调控神经元内合成代谢参与神经退行性疾病。
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注：以上文献为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索确认。
The GPM6A antibody targets the glycoprotein M6A (GPM6A), a member of the proteolipid protein family (PLP/PLP/DM20) predominantly expressed in the central nervous system. GPM6A is a transmembrane protein involved in neuronal differentiation, synaptic plasticity, and regulation of neurotransmitter release. It shares structural homology with myelin proteolipid proteins and is thought to participate in membrane organization, neurite outgrowth, and cholesterol homeostasis. Dysregulation of GPM6A has been implicated in neuropsychiatric disorders, including depression, schizophrenia, and autism spectrum disorders, highlighting its potential role in neural circuit development and function.
Antibodies against GPM6A are widely used in neuroscience research to study its expression patterns, subcellular localization, and interactions. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Commercially available GPM6A antibodies are typically raised in hosts like rabbits or mice, using immunogenic peptides derived from conserved regions of the human or rodent protein. Validation often includes knockout cell lines or tissue controls to confirm specificity. Recent studies have leveraged these antibodies to explore GPM6A's involvement in stress response, axonal guidance, and its interaction with synaptic proteins like neuroligins. However, variability in antibody performance across species or experimental conditions necessitates careful optimization.
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