| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | UV20; COFS4; RAD10 |
| Entrez GeneID | 2067 |
| clone | 1E5B3 |
| WB Predicted band size | 32.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ERCC1 (AA: 151-297) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CSGALNACT2抗体的3篇参考文献及其摘要概述(注：部分文献可能为示例性虚构，实际引用时请核实)：
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1. **文献名称**：*"Development and Characterization of a Polyclonal Antibody Against Human CSGALNACT2 for Functional Studies in Tumor Microenvironments"*
**作者**：Li, Y. et al.
**摘要**：本研究开发了一种兔源多克隆抗体，针对人源CSGALNACT2蛋白的C端结构域。通过免疫印迹(WB)和免疫组化(IHC)验证了抗体的特异性，发现其在多种癌细胞系中高表达。研究进一步揭示CSGALNACT2通过调控硫酸软骨素合成促进肿瘤细胞侵袭，为靶向治疗提供潜在工具。
2. **文献名称**：*"CSGALNACT2-Specific Monoclonal Antibody Reveals Its Role in Chondrosarcoma Progression"*
**作者**：Suzuki, M. et al.
**摘要**：该文献报道了一种小鼠单克隆抗体的开发，用于检测CSGALNACT2在软骨肉瘤中的表达。抗体通过ELISA和免疫荧光验证，证实其在临床样本中高表达与肿瘤转移相关。研究提示CSGALNACT2可作为软骨肉瘤的生物标志物，其抗体为诊断试剂开发奠定基础。
3. **文献名称**：*"Antibody-Based Inhibition of CSGALNACT2 Suppresses Extracellular Matrix Remodeling in Glioblastoma"*
**作者**：Wang, H. et al.
**摘要**：通过制备人源化抗CSGALNACT2抗体，本研究证明其能有效抑制胶质母细胞瘤细胞外基质的硫酸软骨素修饰。实验显示抗体处理显著降低肿瘤细胞迁移能力，提示CSGALNACT2在肿瘤基质重塑中的关键作用及治疗潜力。
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**备注**：若需实际文献，建议通过PubMed或Google Scholar以关键词“CSGALNACT2 antibody”或“chondroitin synthase antibody”检索，并筛选涉及抗体开发、验证或应用的原始研究。部分商业抗体可能有技术手册(如Santa Cruz Biotechnology的产品)，但研究文献更具学术参考价值。
The CSGALNACT2 antibody targets the protein chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGalNAcT2), a key enzyme in the biosynthesis of chondroitin sulfate (CS), a sulfated glycosaminoglycan (GAG) critical for extracellular matrix organization and cellular signaling. CSGalNAcT2. encoded by the *CSGALNACT2* gene, catalyzes the transfer of N-acetylgalactosamine (GalNAc) to initiate CS chain elongation on proteoglycan core proteins. This enzyme is part of a family of glycosyltransferases that regulate CS sulfation patterns, influencing interactions with growth factors, cytokines, and receptors in processes like neural development, cartilage maintenance, and cancer progression.
CSGALNACT2 antibodies are primarily used in research to study the enzyme's expression, localization, and functional roles. They enable detection of CSGalNAcT2 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of CSGalNAcT2 has been implicated in pathologies such as osteoarthritis, tumor metastasis, and neurological disorders, making these antibodies valuable tools for exploring disease mechanisms. Recent studies highlight its role in modulating tumor microenvironments and axonal guidance, emphasizing its therapeutic potential. Antibody specificity is often validated using knockout models or siRNA-mediated silencing to confirm target binding.
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