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Rabbit Polyclonal THOC7 Antibody

  • 中文名: THOC7抗体
  • 别    名: fSAP24; hTREX30; NIF3L1BP1
货号: IPDX08000
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是关于THOC7抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*THOC7 deficiency leads to early-onset recurrent infections and cancer in mice*

**作者**:Mozaffari et al.

**摘要**:该研究通过构建THOC7基因敲除小鼠模型,发现THOC7缺失会导致免疫系统异常,表现为反复感染和癌症易感性增加。研究利用THOC7抗体检测蛋白表达,揭示了THOC7在维持免疫细胞稳态中的关键作用。

2. **文献名称**:*The THO complex component Thoc7 is required for embryonic development and participates in 3′ end processing of histone mRNAs*

**作者**:Guria et al.

**摘要**:文章通过THOC7抗体进行免疫沉淀和染色质分析,发现THOC7在胚胎发育中不可或缺,并参与组蛋白mRNA的3'末端加工。实验表明,THOC7缺失会导致胚胎致死和细胞周期停滞。

3. **文献名称**:*THOC7 binds the replisome to promote synthesis of nascent DNA strands*

**作者**:Dutta et al.

**摘要**:该研究利用THOC7抗体进行免疫荧光和蛋白质互作分析,发现THOC7通过与DNA复制复合体结合,促进新生DNA链的合成。结果表明THOC7在DNA复制和基因组稳定性中具有新功能,与癌症发生相关。

(注:以上文献信息为模拟示例,实际文献需通过PubMed/Google Scholar等平台检索确认。)

背景信息

The THOC7 antibody is a tool used to study the THOC7 protein, a component of the THO complex, which is part of the larger TREX (Transcription-Export) complex involved in mRNA processing and nuclear export. THOC7. along with other THO subunits (THOC1-THOC7), plays a role in coupling transcription elongation with mRNA splicing, packaging, and transport to the cytoplasm. It is essential for maintaining genome stability and proper gene expression, particularly for long or structured transcripts. THOC7 antibodies are primarily utilized in research to investigate its expression, localization, and interactions in cellular processes, such as cell cycle regulation, differentiation, and stress responses. Dysregulation of THOC7 has been implicated in diseases, including certain cancers and neurodevelopmental disorders. For example, studies suggest its overexpression in leukemia and solid tumors, correlating with poor prognosis. These antibodies are critical in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore THOC7’s molecular mechanisms and its role in disease pathways. Their development and validation are vital for advancing understanding of mRNA metabolism defects and potential therapeutic targets.

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