| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TARSH; NESHBP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ABI3BP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABI3BP抗体的3篇参考文献及其摘要内容的简要概括：
1. **文献名称**: "ABI3BP regulates cardiac fibrosis via modulating TGF-β signaling"
**作者**: Zhang Y, et al.
**摘要**: 该研究利用特异性ABI3BP抗体，通过免疫组织化学和Western blot技术，揭示了ABI3BP在心脏纤维化中通过调控TGF-β信号通路的作用，证明其在心肌修复中的潜在治疗靶点价值。
2. **文献名称**: "ABI3BP as a prognostic biomarker in glioblastoma: insights from antibody-based profiling"
**作者**: Lee S, et al.
**摘要**: 通过商业化ABI3BP抗体对胶质母细胞瘤组织样本进行染色，研究发现ABI3BP低表达与患者不良预后显著相关，提示其可作为神经胶质瘤的潜在预后标志物。
3. **文献名称**: "Characterization of a novel monoclonal antibody against ABI3BP and its application in extracellular matrix studies"
**作者**: Tanaka R, et al.
**摘要**: 本研究开发了一种高特异性抗ABI3BP单克隆抗体，并验证其在ELISA和免疫荧光中的应用，证实ABI3BP在细胞外基质重塑中的功能，为相关疾病机制研究提供工具。
4. **文献名称**: "ABI3BP deficiency promotes tumor metastasis through integrin signaling: evidence from antibody-mediated inhibition assays"
**作者**: Chen H, et al.
**摘要**: 使用ABI3BP中和抗体阻断其功能后，发现肿瘤细胞的整合素信号通路异常激活，导致侵袭性增强，表明ABI3BP在抑制肿瘤转移中的关键作用。
注：上述文献为示例性内容，实际研究中请以真实发表的论文为准。若需具体文献，建议通过PubMed或Google Scholar检索关键词“ABI3BP antibody”或结合研究领域进一步筛选。
The ABI3BP (ABI Family Member 3 Binding Protein) antibody is designed to target the ABI3BP protein, a multifunctional molecule implicated in cell adhesion, proliferation, and apoptosis. Initially identified as a binding partner of the Abelson interactor (ABI) family, ABI3BP is encoded by the *ABI3BP* gene and functions as a scaffold protein regulating cellular signaling pathways, particularly those involving the extracellular matrix (ECM). It contains thrombospondin type-1 (TSPN) and integrin-binding domains, suggesting roles in ECM organization and cell-matrix interactions.
Research highlights ABI3BP's dual role in cancer and neurodegenerative diseases. In tumors, it often acts as a tumor suppressor, with reduced expression linked to metastasis and poor prognosis in cancers like lung, breast, and thyroid. Conversely, in neurodegenerative contexts, ABI3BP may influence neuronal survival and synaptic plasticity.
The ABI3BP antibody is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression patterns, localization, and interactions. Its development has advanced investigations into ECM remodeling, cellular senescence, and disease mechanisms, positioning it as a potential biomarker or therapeutic target. Ongoing studies aim to clarify its precise molecular pathways and therapeutic applications.
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