| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ALEX2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ARMCX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ARMCX2抗体的3篇假设参考文献示例(基于领域研究背景推测内容)：
1. **文献名称**：*ARMCX2 regulates mitochondrial trafficking and promotes glioblastoma invasion*
**作者**：Li, Y., et al.
**摘要**：本研究利用ARMCX2特异性抗体，通过免疫荧光和Western blot技术，揭示了ARMCX2通过调控线粒体在细胞内的分布，增强胶质母细胞瘤细胞的迁移和侵袭能力，提示其作为潜在治疗靶点。
2. **文献名称**：*ARMCX2 interacts with the Wnt signaling pathway in neural development*
**作者**：Garcia-Sanchez, P., et al.
**摘要**：作者通过免疫共沉淀(ARMCX2抗体)和基因敲除模型，证明ARMCX2与Wnt通路蛋白相互作用，影响小鼠胚胎神经嵴细胞的定向分化，为神经发育障碍提供机制解释。
3. **文献名称**：*Loss of ARMCX2 expression correlates with poor prognosis in hepatocellular carcinoma*
**作者**：Chen, H., et al.
**摘要**：通过免疫组化(使用抗ARMCX2抗体)分析肝癌组织样本，发现ARMCX2低表达与患者生存期缩短显著相关，其缺失可能通过激活MAPK通路促进肿瘤进展。
(注：以上文献为模拟示例，实际引用需以真实发表文献为准。)
The ARMCX2 antibody is a research tool designed to detect the ARMCX2 protein, encoded by the *ARMCX2* gene (Armadillo Repeat-Containing X-Linked 2). This gene belongs to the ARMCX family located on the X chromosome, implicated in mitochondrial dynamics and intracellular transport. ARMCX2 is thought to regulate mitochondrial trafficking, particularly in neurons, by interacting with proteins like MIRO-1. which coordinates mitochondrial movement along microtubules. Dysregulation of ARMCX2 has been associated with neurodevelopmental disorders, cancer progression, and metabolic diseases, as it may influence cell migration, proliferation, and apoptosis.
ARMCX2 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and function in cellular and tissue contexts. Researchers employ these antibodies to explore ARMCX2's role in diseases like glioblastoma or neuroblastoma, where its expression is often altered. Commercially available antibodies are typically validated for specificity using knockout controls or siRNA-mediated silencing.
Despite its potential significance, ARMCX2's exact molecular mechanisms remain under investigation. The antibody thus serves as a critical reagent for elucidating its biological contributions to mitochondrial homeostasis, neuronal function, and disease pathways, offering insights for therapeutic targeting.
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